术前 F-18 氟代脱氧葡萄糖 PET/CT 在不可切除转移的结直肠癌中的预后价值。

Prognostic value of pretreatment F-18 fluorodeoxyglucose PET/CT in colorectal cancer with unresectable metastasis.

机构信息

Department of Radiology, Incheon St.Mary's Hospital, College of Medicine, The Catholic University of Korea.

Department of Nuclear Medicine, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea.

出版信息

Nucl Med Commun. 2021 Jun 1;42(6):639-645. doi: 10.1097/MNM.0000000000001384.

DOI:10.1097/MNM.0000000000001384

PMID:33625189

Abstract

PURPOSE

The aim of the study was to assess the prognostic value of pretreatment PET/computed tomography (CT) scans in colorectal cancer (CRC) patients with unresectable metastasis.

MATERIALS AND METHODS

We retrospectively reviewed the pretreatment PET/CT images of 82 CRC patients with unresectable metastasis and their medical records. On PET/CT images, maximum standardized uptake value (SUVmax) of primary tumor, highest SUVmax of metastatic tumors and number of metastatic organs were identified. The patients were further divided into single and multiple organ metastases groups according to the extent of disease. Survival analysis was performed with the clinical variables and metabolic parameters from PET/CT.

RESULTS

In a total of 82 patients, the age of patients, highest SUVmax of metastatic tumors and number of metastatic organs were independent prognostic factors for overall survival (OS) (all P < 0.05), whereas the SUVmax of primary tumor was not. On multivariate analysis, only the SUVmax of metastatic tumor was a significant prognostic factor in the single organ metastasis group (P = 0.047), whereas the age and highest SUVmax of metastatic tumors were independent prognostic factors in the multiple organ metastases group (all P < 0.05).

CONCLUSION

The highest SUVmax of metastatic tumors was an independent prognostic factor for OS in CRC patients with unresectable metastasis.

摘要

目的

本研究旨在评估无法切除转移的结直肠癌（CRC）患者治疗前正电子发射断层扫描/计算机断层扫描（PET/CT）扫描的预后价值。

材料与方法

我们回顾性分析了 82 例无法切除转移的 CRC 患者的治疗前 PET/CT 图像及其病历。在 PET/CT 图像上，确定了原发肿瘤的最大标准化摄取值（SUVmax）、转移瘤的最大 SUVmax 和转移器官的数量。根据疾病的严重程度，患者进一步分为单发器官转移组和多发器官转移组。对来自 PET/CT 的临床变量和代谢参数进行生存分析。

结果

在总共 82 例患者中，患者年龄、转移瘤的最大 SUVmax 和转移器官数量是总生存期（OS）的独立预后因素（均 P<0.05），而原发肿瘤的 SUVmax 则不是。多变量分析显示，只有转移瘤的 SUVmax 是单发器官转移组的显著预后因素（P=0.047），而在多发器官转移组中，患者年龄和转移瘤的最大 SUVmax 是独立的预后因素（均 P<0.05）。