Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Institute of Cardiovascular Disease, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Biosci Trends. 2021 Mar 15;15(1):58-60. doi: 10.5582/bst.2020.03429. Epub 2021 Feb 23.
Bone morphogenetic protein 4 (BMP4) was recently reported to confer reprogramming capability to embryonic stem cells (ESCs) by reactivating naïve pluripotency genes via Zbtb7a and Zbtb7b. A visual reporting system was developed to first identify BMP4 as a driver for the primed-to-naïve transition (PNT). In addition, two specific inhibitors were identified as significantly improving the efficiency of PNT (~80% transition) within 8 days. The Zbtb7 family members were first introduced in the context of PNT and stem cell fate decision-making. These findings provide valuable information on acquiring naïve pluripotent stem cells for regenerative medicine.
骨形态发生蛋白 4（BMP4）最近被报道通过 Zbtb7a 和 Zbtb7b 重新激活原始多能性基因，从而赋予胚胎干细胞（ESC）重编程能力。开发了一个可视化报告系统，首先将 BMP4 鉴定为启动到原始状态转变（PNT）的驱动因素。此外，还鉴定出两种特定抑制剂可显著提高 PNT 的效率（8 天内约 80%的转化率）。Zbtb7 家族成员首先在 PNT 和干细胞命运决策的背景下被引入。这些发现为获得用于再生医学的原始多能干细胞提供了有价值的信息。
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