INSM1 在脊索瘤中的表达。
INSM1 Expression in Chordomas.
机构信息
Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
Pathology Department, University Hospital of Grenoble, Grenoble, France.
出版信息
Am J Clin Pathol. 2021 Aug 4;156(3):334-339. doi: 10.1093/ajcp/aqaa250.
OBJECTIVES
Chordomas are rare malignant tumors with a broad differential diagnosis, including chondrosarcomas and metastatic carcinomas. Recently, insulinoma-associated protein 1 (INSM1) has gained great interest regarding the diagnosis of neuroendocrine tumors but also extraskeletal myxoid chondrosarcomas. However, its expression in chordomas remains largely unknown.
METHODS
We retrospectively examined 57 chordomas for INSM1 expression.
RESULTS
INSM1 expression was found in only 5% of tumors.
CONCLUSIONS
This marker is rarely expressed in this type of tumor, raising questions about neuroendocrine differentiation.
目的
脊索瘤是一种罕见的恶性肿瘤，其鉴别诊断广泛，包括软骨肉瘤和转移性癌。最近，胰岛素瘤相关蛋白 1（INSM1）在神经内分泌肿瘤的诊断中引起了极大的关注，但也包括 extraskeletal myxoid chondrosarcomas。然而，其在脊索瘤中的表达仍知之甚少。
方法
我们回顾性地检查了 57 例脊索瘤的 INSM1 表达。
结果
仅 5%的肿瘤表达 INSM1。
结论
这种标志物在这种类型的肿瘤中很少表达，这引发了关于神经内分泌分化的问题。
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