68Ga-DOTATATE PET/CT 成像表现酷似颈副神经节瘤的鳞状细胞癌
Squamous Cell Carcinoma Mimicking Neck Paraganglioma on 68Ga-DOTATATE PET/CT.
机构信息
From the Departments of Nuclear Medicine.
Ear, Nose, and Throat Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
出版信息
Clin Nucl Med. 2021 Jul 1;46(7):e368-e370. doi: 10.1097/RLU.0000000000003555.
Somatostatin receptor (SSTR) imaging with 68Ga-labeled somatostatin analogs has been used for many tumors with high SSTR expression. Increased uptake mostly depends on the SSTR status of tumors; however, false-positive uptake can be demonstrated in benign diseases or other malignancies because of the increased SSTR expression. We present a case of a 50-year-old man with increased SSTR activity on cervical lesion located in internal jugular chain in 68Ga-DOTATATE PET/CT, which was performed for suspicion of paraganglioma. Biopsy revealed lymph node metastasis of squamous cell carcinoma other than paraganglioma. 18F-FDG PET/CT showed primary malignancy on larynx and lymph node metastasis, which were correlated surgically.
采用 68Ga 标记的生长抑素类似物进行生长抑素受体 (SSTR) 成像已被用于许多高 SSTR 表达的肿瘤。摄取增加主要取决于肿瘤的 SSTR 状态;然而,由于 SSTR 表达增加,良性疾病或其他恶性肿瘤也可能出现假阳性摄取。我们报告了一例 50 岁男性患者,在怀疑为副神经节瘤而进行的 68Ga-DOTATATE PET/CT 中,颈内静脉链的颈椎病变部位 SSTR 活性增加。活检显示副神经节瘤以外的鳞状细胞癌淋巴结转移。18F-FDG PET/CT 显示喉和淋巴结转移的原发性恶性肿瘤,与手术相关。