Yousem D M, Gatewood O M, Goldman S M, Marshall F F
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Radiology. 1988 Jun;167(3):613-8. doi: 10.1148/radiology.167.3.3363119.
Six hundred forty-five cases of transitional cell carcinoma (TCC) of the bladder, ureter, and/or kidney were reviewed retrospectively to determine the frequency of synchronous and metachronous lesions elsewhere in the urinary tract. Among 597 patients with TCC of the bladder, 23 (3.9%) developed an upper-tract lesion, after an average delay of 61 months. Metachronous upper-tract tumors developed in 13% of 38 patients with primary ureteral TCC and in 11% of 63 with renal TCC, after average delays of 28 and 22 months, respectively. Synchronous TCC was found in 2.3% of patients with bladder TCC, 39% of those with ureteral TCC, and 24% of those with renal TCC. Seventeen percent of the subsequent upper-tract lesions would have been demonstrated by intravenous or retrograde urography performed 1 year after the initial onset of primary bladder cancer, and 61% would have been demonstrated by studies performed within 2 years. Therefore, the authors recommend annual radiologic evaluation of the upper urinary tract for 2 years after initial diagnosis and treatment of an upper-tract or bladder TCC.
对645例膀胱、输尿管和/或肾脏移行细胞癌（TCC）病例进行回顾性分析，以确定尿路其他部位同步和异时性病变的发生率。在597例膀胱TCC患者中，23例（3.9%）出现上尿路病变，平均延迟61个月。38例原发性输尿管TCC患者中有13%、63例肾TCC患者中有11%出现异时性上尿路肿瘤，平均延迟分别为28个月和22个月。膀胱TCC患者中有2.3%、输尿管TCC患者中有39%、肾TCC患者中有24%发现同步TCC。在原发性膀胱癌初次发病1年后进行的静脉或逆行尿路造影可发现17%的后续上尿路病变，2年内进行的检查可发现61%的病变。因此，作者建议在上尿路或膀胱TCC初次诊断和治疗后2年内每年对上尿路进行影像学评估。
