VSIG4 基因多态性对类风湿关节炎易感性和功能状态的影响。
Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.
机构信息
Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
Department of Medicine, Positive University, Curitiba, Brazil.
出版信息
Int J Immunogenet. 2021 Jun;48(3):260-265. doi: 10.1111/iji.12533. Epub 2021 Mar 1.
PMID:33645007
Abstract
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.
摘要
免疫球蛋白超家族的补体受体（CRIg，由 VSIG4 基因编码）是一种参与清除免疫复合物和自身细胞的巨噬细胞受体。我们的研究结果表明，VSIG4 rs1044165T 等位基因是女性类风湿关节炎严重功能状态的危险因素，可能通过影响 VSIG4 基因表达。
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