Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
Department of Medicine, Positive University, Curitiba, Brazil.
Int J Immunogenet. 2021 Jun;48(3):260-265. doi: 10.1111/iji.12533. Epub 2021 Mar 1.
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.
免疫球蛋白超家族的补体受体（CRIg，由 VSIG4 基因编码）是一种参与清除免疫复合物和自身细胞的巨噬细胞受体。我们的研究结果表明，VSIG4 rs1044165T 等位基因是女性类风湿关节炎严重功能状态的危险因素，可能通过影响 VSIG4 基因表达。
