Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
N Z Med J. 2021 Feb 19;134(1530):38-47.
We aimed to assess the use of and attitudes towards cannabis use (medicinal and recreational) by people with IBD in New Zealand.
People with IBD were invited to complete an anonymous online questionnaire. Participants were recruited via postal mail using a hospital database of patients with IBD (developed by the Gas-troenterology Department at Dunedin Public Hospital) and via online recruitment (advertised on the Crohn's and Colitis New Zealand website, Facebook page and e-mail list). Inclusion criteria were ages 18+ and self-reported confirmed IBD diagnosis.
In total, 378 participants completed the questionnaire, with 334 eligible responses. Partici-pants were predominantly New Zealand European (84%) and female (71%). Sixty-one percent of re-spondents had CD and 34% UC. Overall, 51% of respondents reported having ever used cannabis. Of those, 63% reported use as recreational and 31% for reduction of IBD symptoms. Users were more likely to be younger (on average by 6.4 years), with on-going symptoms, unemployed or self-employed and current or ex-smokers. There were no differences by disease status or severity. Symp-toms most reported as improved by cannabis use were abdominal pain/cramping, nausea/vomiting and loss of appetite. Fifty-four percent of participants reported that if cannabis were legal, they would request it for medicinal use to help manage their symptoms.
Overall, our research aligns with previous observational research that reports im-provements in symptoms of IBD with cannabis use. Studies of a higher evidence level (eg, RCTs) would be needed to guide prescribing. In the meantime, this research provides useful background to clini-cians about patients' views and experiences.
我们旨在评估新西兰炎症性肠病(IBD)患者对大麻使用(药用和娱乐)的使用情况和态度。
我们邀请 IBD 患者完成一份匿名在线问卷。参与者通过医院的 IBD 患者数据库(由达尼丁公立医院胃肠科开发)和在线招募(在新西兰克罗恩病和结肠炎网站、Facebook 页面和电子邮件列表上发布广告)进行招募。纳入标准为年龄在 18 岁及以上且自我报告确诊为 IBD。
共有 378 名参与者完成了问卷,其中 334 名符合条件。参与者主要为新西兰欧洲人(84%)和女性(71%)。61%的受访者患有 CD,34%患有 UC。总体而言,51%的受访者报告曾使用过大麻。其中,63%的人报告使用大麻是为了娱乐,31%的人是为了减轻 IBD 症状。使用者更年轻(平均年轻 6.4 岁),有持续症状,失业或自营职业,且目前或曾经吸烟。疾病状况或严重程度没有差异。报告大麻使用改善的症状主要有腹痛/痉挛、恶心/呕吐和食欲不振。54%的参与者表示,如果大麻合法化,他们将要求将其用于医疗用途,以帮助控制他们的症状。
总的来说,我们的研究与之前报告大麻使用可改善 IBD 症状的观察性研究一致。需要更高证据水平(例如 RCT)的研究来指导处方。与此同时,这项研究为临床医生提供了有关患者观点和经验的有用背景。