Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Pathology, Emory University, Atlanta, GA, USA.
Ann Clin Lab Sci. 2021 Jan;51(1):124-130.
EBV positive mucocutaneous ulcer (EBVMCU) is a newly recognized clinicopathologic entity in the 2017 World Health Organization (WHO) classification. Patients frequently present with an isolated ulcerative lesion in mucosal and cutaneous sites with immunosuppression as the main risk factor. The disease typically follows an indolent clinical course. Herein we describe a series of three patients diagnosed with EBVMCU. Histopathologic examination of these cases shows ulceration in mucosal or cutaneous surface with a substantial number of large atypical transformed cells in the background of dense polymorphous infiltrates. One patient regressed spontaneously with no treatment, one patient needed Rutiximab, and one patient had persistent EBVMCU process with possible transformation to large B cell lymphoma. The aim of the present case series is to highlight the pathologic, diagnostic and clinical features of patients with EBVMCU.
EBV 阳性黏膜皮肤溃疡（EBVMCU）是 2017 年世界卫生组织（WHO）分类中新认定的临床病理实体。患者常因免疫抑制而出现孤立性黏膜和皮肤溃疡病变，这是主要的风险因素。该疾病通常具有惰性的临床病程。本文描述了三例 EBVMCU 患者。这些病例的组织病理学检查显示黏膜或皮肤表面溃疡，背景中存在大量大量异型转化细胞，伴密集多形性浸润。一例患者未经治疗自发消退，一例患者需要 Rutiximab 治疗，一例患者 EBVMCU 持续存在，可能向大 B 细胞淋巴瘤转化。本病例系列的目的是强调 EBVMCU 患者的病理、诊断和临床特征。
