Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Physiol Res. 2020 Dec 31;69(Suppl 4):S649-S659. doi: 10.33549/physiolres.934614.
The healthy development of the fetus depends on the exact course of pregnancy and delivery. Therefore, prenatal hypoxia remains between the greatest threats to the developing fetus. Our study aimed to assess the impact of prenatal hypoxia on postnatal development and behavior of the rats, whose mothers were exposed to hypoxia (10.5 % O2) during a critical period of brain development on GD20 for 12 h. This prenatal insult resulted in a delay of sensorimotor development of hypoxic pups compared to the control group. Hypoxic pups also had lowered postnatal weight which in males persisted up to adulthood. In adulthood, hypoxic males showed anxiety-like behavior in the OF, higher sucrose preference, and lower levels of grimace scale (reflecting the degree of negative emotions) in the immobilization chamber compared to the control group. Moreover, hypoxic animals showed hyperactivity in EPM and LD tests, and hypoxic females had reduced sociability compared to the control group. In conclusion, our results indicate a possible relationship between prenatal hypoxia and changes in sociability, activity, and impaired emotion regulation in ADHD, ASD, or anxiety disorders. The fact that changes in observed parameters are manifested mostly in males confirms that male sex is more sensitive to prenatal insults.
胎儿的健康发育取决于妊娠和分娩的准确过程。因此，产前缺氧仍然是对发育中胎儿最大的威胁之一。我们的研究旨在评估产前缺氧对其后代发育和行为的影响，方法是使处于大脑发育关键期的孕 20 天（GD20）的母鼠暴露于 10.5%的缺氧环境 12 小时。与对照组相比，这种产前刺激导致缺氧幼鼠的感觉运动发育延迟。缺氧幼鼠的出生后体重也较低，雄性幼鼠的体重一直持续到成年。在成年期，与对照组相比，缺氧雄性大鼠在旷场中表现出焦虑样行为，更喜欢蔗糖，在束缚室中的痛苦表情评分（反映负面情绪的程度）较低。此外，与对照组相比，缺氧动物在 EPM 和 LD 测试中表现出过度活跃，而缺氧雌性动物的社交能力降低。总之，我们的研究结果表明，产前缺氧可能与 ADHD、ASD 或焦虑障碍中的社交能力、活动和情绪调节受损变化有关。观察到的参数变化主要在雄性中表现出来，这一事实证实了雄性对产前刺激更敏感。
