Wicha Piyawadee, Das Srijit, Mahakkanukrauh Pasuk
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Anat Cell Biol. 2021 Jun 30;54(2):165-177. doi: 10.5115/acb.20.290.
Ischemic stroke caused by occlusion of cerebral artery is responsible for the majority of stroke that increases the morbidity and mortality worldwide. Diabetes mellitus (DM) is a crucial risk factor for ischemic stroke. Prolonged DM causes various microvascular and macrovascular changes, and blood-brain barrier (BBB) permeability that facilitates inflammatory response following stroke. In the acute phase following stroke, BBB disruption has been considered the initial step that induces neurological deficit and functional disabilities. Stroke outcomes are significantly worse among DM. In this article, we review stroke with diabetes-induce BBB damage, as well as underlying mechanism and possible therapeutic targets for stroke with diabetes.
由脑动脉闭塞引起的缺血性中风是导致全球发病率和死亡率上升的主要中风类型。糖尿病（DM）是缺血性中风的关键危险因素。长期的糖尿病会导致各种微血管和大血管变化，以及血脑屏障（BBB）通透性增加，从而促进中风后的炎症反应。在中风后的急性期，血脑屏障破坏被认为是导致神经功能缺损和功能障碍的第一步。糖尿病患者的中风预后明显更差。在本文中，我们综述了糖尿病诱导血脑屏障损伤的中风，以及糖尿病中风的潜在机制和可能的治疗靶点。
