基于渐变折射率光纤尖端实现的片上吸收光谱法。
On-chip absorption spectroscopy enabled by graded index fiber tips.
作者信息
Gill Kamalpreet K, Riesen Nicolas, Priest Craig, Phillips Nicholas, Guan Bin, Lancaster David G
机构信息
Future Industries Institute and STEM, University of South Australia, Mawson Lakes, SA 5095, Australia.
ARC Research Hub for Integrated Devices for End-user Analysis at Low-levels (IDEAL), UniSA STEM, University of South Australia, Mawson Lakes, SA 5095, Australia.
出版信息
Biomed Opt Express. 2020 Dec 8;12(1):181-190. doi: 10.1364/BOE.414239. eCollection 2021 Jan 1.
This paper describes the design and characterization of miniaturized optofluidic devices for sensing based on integrating collimating optical fibers with custom microfluidic chips. The use of collimating graded-index fiber (GIF) tips allows for effective fiber-channel-fiber interfaces to be realized when compared with using highly-divergent standard single-mode fiber (SMF). The reduction in both beam divergence and insertion losses for the GIF configuration compared with SMF was characterized for a 10.0 mm channel. Absorption spectroscopy was demonstrated on chip for the measurement of red color dye (Ponceau 4R), and the detection of thiocyanate in water and artificial human saliva. The proposed optofluidic setup allows for absorption spectroscopy measurements to be performed with only 200 µL of solution which is an order of magnitude smaller than for standard cuvettes but provides a comparable sensitivity. The approach could be integrated into a lab-on-a-chip system that is compact and does not require free-space optics to perform absorption spectroscopy.
本文描述了基于将准直光纤与定制微流控芯片集成的用于传感的小型化光流控装置的设计与特性。与使用高度发散的标准单模光纤（SMF）相比，使用准直渐变折射率光纤（GIF）尖端可实现有效的光纤-通道-光纤接口。针对10.0毫米通道，表征了与SMF相比GIF配置在光束发散和插入损耗方面的降低情况。在芯片上展示了用于测量红色染料（丽春红4R）以及检测水中和人工唾液中硫氰酸盐的吸收光谱。所提出的光流控装置允许仅用200微升溶液进行吸收光谱测量，这比标准比色皿小一个数量级，但提供了相当的灵敏度。该方法可集成到紧凑的芯片实验室系统中，且执行吸收光谱无需自由空间光学元件。
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