College of Veterinary Medicine, Huazhong Agricultural University, Rm 321 Vet. Teaching Hospital BLDG, No.1 Shizishan St., Hongshan District, Wuhan City, 430070, Hubei Province, China.
Sci Rep. 2021 Mar 4;11(1):5208. doi: 10.1038/s41598-021-84754-0.
Feline infectious peritonitis (FIP) is a systemic, potentially fatal viral disease. The objectives of this study were to review clinical and laboratory features and treatment of cats highly suspected of FIP in Wuhan, China. The clinical records of 127 cats highly suspected of FIP were reviewed for history, clinical signs, physical findings, and diagnostic test results. Sex, neutering status, breed, age, and month of onset of disease were compared with the characteristics of the clinic population. Age and neutering status were significantly correlated with FIP-suspicion. Sex, breed and onset month were not associated with FIP. There were many more FIP-suspected cases in cats in young cats or male intact cats. Effusion was observed in 85.8% of the FIP-suspected cats. Increased serum amyloid A (SAA) and lymphopenia were common laboratory abnormalities in the FIP cases. Furthermore, 91.7% of the cats highly suspected of FIP had an albumin/globulin (A/G) ratio < 0.6, while 85.3% had an A/G ratio < 0.5. The mortality rate for FIP-suspected cats was 67%, and six submitted cases were confirmed by FIP-specific immunohistochemistry. Of the 30 cats treated with GS-441524 and/or GC376, 29 were clinically cured. The study highlights the diverse range of clinical manifestations by clinicians in diagnosing this potentially fatal disease. A/G ratio and SAA were of higher diagnostic value. GS-441524 and GC376 were efficient for the treatment of FIP-suspected cats.
猫传染性腹膜炎（Feline infectious peritonitis，FIP）是一种系统性、潜在致命的病毒性疾病。本研究的目的是回顾中国武汉高度疑似 FIP 的猫的临床和实验室特征及治疗方法。回顾了 127 例高度疑似 FIP 的猫的临床记录，包括病史、临床症状、体格检查和诊断性检测结果。比较了性别、去势状态、品种、年龄和发病月份与临床人群特征的关系。年龄和去势状态与 FIP 可疑度显著相关。性别、品种和发病月份与 FIP 无关。在幼猫或雄性未去势猫中，FIP 可疑病例更多。85.8%的 FIP 可疑猫有渗出。FIP 病例中常见的实验室异常包括血清淀粉样蛋白 A（Serum amyloid A，SAA）增加和淋巴细胞减少。此外，91.7%的高度疑似 FIP 的猫白蛋白/球蛋白（Albumin/globulin，A/G）比值<0.6，85.3%的 A/G 比值<0.5。FIP 可疑猫的死亡率为 67%，6 例送检病例通过 FIP 特异性免疫组化得到确诊。30 例接受 GS-441524 和/或 GC376 治疗的猫中，29 例临床治愈。本研究强调了临床医生在诊断这种潜在致命疾病时临床表现的多样性。A/G 比值和 SAA 具有更高的诊断价值。GS-441524 和 GC376 对治疗 FIP 可疑猫有效。
