Martínez-Ponce Julia Carel, Mejía-Ávila Mayra, Vázquez-López Saúl, Pou-Aguilar Yuri Nohemí, Ortiz-Farias Diana Lizbeth, Cortes-Telles Arturo
Secretaría de Salud, Hospital Regional de Alta Especialidad de la Península de Yucatán, Departamento de Neumología y Cirugía del Tórax, Mérida, Yucatán, México.
Secretaría de Salud, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Clínica de Enfermedades Intersticiales del Pulmón, Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2021 Feb 2;59(1):55-64. doi: 10.24875/RMIMSS.M21000052.
Interstitial lung disease (ILD) corresponds to a heterogeneous group of pathologies that differ in etiology with common clinical and radiological manifestations. In Latin America and Mexico, reports are scarce and the need for studies to understand the scenario is emphasized.
To analyze a multidimensional profile in patients with interstitial lung disease in Yucatan.
This is an observational, prospective, analytic, descriptive study including consecutive patients diagnosed with ILD over a 4-year period. Demographic and clinical data, lung function tests, chest imaging, serum immunological profile, and echocardiographic findings were recorded. Differences between subgroups were analyzed performing a one-way analysis of variance (ANOVA).
110 patients were included. The median age was 60 years and women were most affected. The main cause of ILD was related with connective tissue diseases (CTD). A group subanalysis revealed that Idiopathic pulmonary fibrosis (IPF) was common in males with a history of smoking and an imaging pattern of usual interstitial pneumonia. Lung function tests showed a moderate-to-severe pulmonary restriction (FVC 55%p) and mild hypoxemia (PaO2 79mmHg). Positive antinuclear antibodies are less likely in cases with IPF (20 vs. 65%; p = 0.006).
In Southeastern Mexico, ILD occurs in women in their seventh decade of life; the most common cause is related with CTD. Our results support that ILD has a heterogeneous expression and is relevant the need for subsequent studies characterizing each ILD.
间质性肺疾病(ILD)是一组病因各异但具有共同临床和影像学表现的异质性病理状况。在拉丁美洲和墨西哥,相关报告较少,强调需要开展研究以了解实际情况。
分析尤卡坦半岛间质性肺疾病患者的多维特征。
这是一项观察性、前瞻性、分析性、描述性研究,纳入了连续4年被诊断为ILD的患者。记录了人口统计学和临床数据、肺功能测试、胸部影像学、血清免疫学特征以及超声心动图检查结果。通过单因素方差分析(ANOVA)分析亚组之间的差异。
纳入了110例患者。中位年龄为60岁,女性受影响最为严重。ILD的主要病因与结缔组织病(CTD)有关。亚组分析显示,特发性肺纤维化(IPF)在有吸烟史且具有普通型间质性肺炎影像学表现的男性中较为常见。肺功能测试显示为中度至重度肺功能受限(FVC 55%预计值)和轻度低氧血症(PaO2 79mmHg)。IPF患者抗核抗体阳性的可能性较小(20%对65%;p = 0.006)。
在墨西哥东南部,ILD发生于70岁左右的女性;最常见的病因与CTD有关。我们的结果支持ILD具有异质性表现,并且后续开展针对每种ILD特征的研究很有必要。