Merkow David B, Tang Alex, Iorio Richard, Slover James D, Bosco Joseph A, Schwarzkopf Ran
Department of Orthopedic Surgery, NYU Langone Health, New York, NY, USA.
Brigham and Women's Hospital, Boston, MA, USA.
J Orthop. 2021 Feb 12;24:26-28. doi: 10.1016/j.jor.2021.02.005. eCollection 2021 Mar-Apr.
Venous thromboembolism (VTE) is a known complication after total knee arthroplasty (TKA) with well-established morbidity, mortality, and significant healthcare expenditure. However, no standard form of prophylaxis against VTE currently exists.
A retrospective review was performed identifying 12,866 TKA cases and post-operative VTE events using either 325 mg aspirin or 81 mg aspirin twice daily (BID).
133 VTE cases were diagnosed of the 9413 TKA on 325 mg aspirin BID compared to 8 VTE cases out of 3453 TKA on 81 mg aspirin BID (1.41% vs. 0.23%, p < 0.001).
81 mg aspirin BID significantly improved post-operative VTE rates over 325 mg aspirin BID.
静脉血栓栓塞症（VTE）是全膝关节置换术（TKA）后已知的并发症，具有明确的发病率、死亡率，并导致大量医疗费用支出。然而，目前尚无预防VTE的标准方法。
进行了一项回顾性研究，确定了12866例TKA病例以及使用每日两次（BID）325毫克阿司匹林或81毫克阿司匹林后的术后VTE事件。
在9413例接受每日两次325毫克阿司匹林治疗的TKA病例中，诊断出133例VTE病例，而在3453例接受每日两次81毫克阿司匹林治疗的TKA病例中，有8例VTE病例（1.41%对0.23%，p<0.001）。
与每日两次325毫克阿司匹林相比，每日两次81毫克阿司匹林显著降低了术后VTE发生率。
