低剂量阿司匹林对接受初次全膝关节置换术的患者预防静脉血栓栓塞有效。
Low dose aspirin is effective in preventing venous thromboembolism in patients undergoing primary total knee arthroplasty.
作者信息
Merkow David B, Tang Alex, Iorio Richard, Slover James D, Bosco Joseph A, Schwarzkopf Ran
机构信息
Department of Orthopedic Surgery, NYU Langone Health, New York, NY, USA.
Brigham and Women's Hospital, Boston, MA, USA.
出版信息
J Orthop. 2021 Feb 12;24:26-28. doi: 10.1016/j.jor.2021.02.005. eCollection 2021 Mar-Apr.
Abstract
INTRODUCTION
Venous thromboembolism (VTE) is a known complication after total knee arthroplasty (TKA) with well-established morbidity, mortality, and significant healthcare expenditure. However, no standard form of prophylaxis against VTE currently exists.
METHODS
A retrospective review was performed identifying 12,866 TKA cases and post-operative VTE events using either 325 mg aspirin or 81 mg aspirin twice daily (BID).
RESULTS
133 VTE cases were diagnosed of the 9413 TKA on 325 mg aspirin BID compared to 8 VTE cases out of 3453 TKA on 81 mg aspirin BID (1.41% vs. 0.23%, p < 0.001).
CONCLUSION
81 mg aspirin BID significantly improved post-operative VTE rates over 325 mg aspirin BID.
摘要
引言
静脉血栓栓塞症（VTE）是全膝关节置换术（TKA）后已知的并发症，具有明确的发病率、死亡率，并导致大量医疗费用支出。然而，目前尚无预防VTE的标准方法。
方法
进行了一项回顾性研究，确定了12866例TKA病例以及使用每日两次（BID）325毫克阿司匹林或81毫克阿司匹林后的术后VTE事件。
结果
在9413例接受每日两次325毫克阿司匹林治疗的TKA病例中，诊断出133例VTE病例，而在3453例接受每日两次81毫克阿司匹林治疗的TKA病例中，有8例VTE病例（1.41%对0.23%，p<0.001）。
结论
与每日两次325毫克阿司匹林相比，每日两次81毫克阿司匹林显著降低了术后VTE发生率。
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2
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J Bone Joint Surg Am. 2017 Jan 18;99(2):91-98. doi: 10.2106/JBJS.16.00147.
3
The Incidence and Economic Burden of In-Hospital Venous Thromboembolism in the United States.
J Arthroplasty. 2017 Apr;32(4):1063-1066. doi: 10.1016/j.arth.2016.10.020. Epub 2016 Oct 21.
4
Risk-Stratified Venous Thromboembolism Prophylaxis After Total Joint Arthroplasty: Aspirin and Sequential Pneumatic Compression Devices vs Aggressive Chemoprophylaxis.
J Arthroplasty. 2016 Sep;31(9 Suppl):78-82. doi: 10.1016/j.arth.2016.01.065. Epub 2016 Mar 16.
5
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Thromb Res. 2016 Mar;139:121-4. doi: 10.1016/j.thromres.2016.01.021. Epub 2016 Jan 27.
6
Complications related to therapeutic anticoagulation in total hip arthroplasty.
J Arthroplasty. 2013 Jan;28(1):187-92. doi: 10.1016/j.arth.2012.06.001.
7
Recent Korean perspective of deep vein thrombosis after total knee arthroplasty.
J Arthroplasty. 2011 Oct;26(7):1112-6. doi: 10.1016/j.arth.2011.02.021. Epub 2011 Apr 6.
8
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9
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