Department of Surgery and Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States.
Front Immunol. 2021 Feb 17;12:634544. doi: 10.3389/fimmu.2021.634544. eCollection 2021.
B cell differentiation and memory are controlled by the transmembrane activator and CAML interactor (TACI), a receptor encoded by . mutations are frequently found in common variable immunodeficiency (CVID) and in IgA -deficiency; yet, ~98% of those with mutant are healthy. Indeed, is among the 5% most polymorphic genes in man. Other mammals evidence polymorphism at comparable loci. We hypothesize that diversity might promote rather than detract from well-being by controlling key elements of innate immunity. We shall discuss how extraordinary diversity of could have evolved and persisted across diverse species of mammals by controlling innate and adaptive B cell responses in apparently paradoxical ways.
B 细胞分化和记忆受跨膜激活剂和钙调亲环素相互作用蛋白（TACI）调控，该受体由 编码。 突变在常见可变免疫缺陷（CVID）和 IgA 缺乏症中经常发现；然而，约 98%的突变 患者是健康的。事实上， 是人类中第 5 大多态性基因之一。其他哺乳动物在类似的基因座也表现出多态性。我们假设， 多样性可能通过以看似矛盾的方式控制先天和适应性 B 细胞反应，从而促进而不是损害健康。我们将讨论通过以明显矛盾的方式控制先天和适应性 B 细胞反应， 如何在不同的哺乳动物物种中进化和持续存在，具有如此非凡的多样性。
