Nørgaard Mette, Horváth-Puhó Erzsébet, Corraini Priscila, Sørensen Henrik Toft, Henderson Victor W
Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Olof Palmes Allé 43-45, DK-8200 Aarhus N, Denmark.
Department of Epidemiology and Population Health, Stanford University, 259 Campus Drive, Stanford, CA 94305-5405, United States.
EClinicalMedicine. 2021 Feb 3;32:100740. doi: 10.1016/j.eclinm.2021.100740. eCollection 2021 Feb.
Sleep disturbances may increase risks of Alzheimer's disease (AD) and other dementias. Benign prostatic hyperplasia (BPH) is usually associated with lower urinary tract symptoms, including nocturia, and thereby disturbed sleep. We examined if men with BPH are at increased risk of AD and all-cause dementia.
In a Danish nationwide cohort (1996-2016), we identified 297,026 men with BPH, defined by inpatient or outpatient hospital diagnosis or by BPH-related surgical or medical treatment, and 1,107,176 men from the general population matched by birth year. We computed rates, cumulative incidences, and adjusted hazard ratios (HRs) of AD and all-cause dementia. Follow-up started 1 year after BPH diagnosis date/index date.
Median follow-up was 6·9 years (Interquartile range (IQR), 3·6 - 11·6 years] in the BPH cohort and 6·4 years (IQR: 3·4 - 10·8 years) in the comparison cohort. The cumulative 1-10 year risk of AD was 1·15% [95% confidence interval (CI), 1·11-1·20], in the BPH cohort and 1·00% (95% CI, 0·98 - 1·02) in the comparison cohort. The adjusted 1-10-year hazard ratios were 1·16 (95% CI: 1·10-1·21) for AD and 1·21 (95% CI: 1·17-1·25) for all-cause dementia. From >10 years up to 21 years of follow-up, BPH remained associated with 10%- 20% increased risk of AD and all-cause dementia.
During up to 21 years of follow-up, men with BPH had persistently higher risk of AD and all-cause dementia compared with men in the general population. Our results identify BPH as a common, potentially remediable disorder associated with dementia risk.
Lundbeckfonden, Aarhus University Research Foundation, and the National Institutes of Health.
睡眠障碍可能会增加患阿尔茨海默病（AD）和其他痴呆症的风险。良性前列腺增生（BPH）通常与下尿路症状相关，包括夜尿症，从而扰乱睡眠。我们研究了患有BPH的男性患AD和全因痴呆症的风险是否增加。
在丹麦全国队列（1996 - 2016年）中，我们确定了297,026名患有BPH的男性，其定义为住院或门诊医院诊断或与BPH相关的手术或药物治疗，以及1,107,176名按出生年份匹配的普通人群男性。我们计算了AD和全因痴呆症的发病率、累积发病率和调整后的风险比（HRs）。随访从BPH诊断日期/索引日期后1年开始。
BPH队列的中位随访时间为6.9年（四分位间距（IQR），3.6 - 11.6年），比较队列的中位随访时间为6.4年（IQR：3.4 - 10.8年）。BPH队列中AD的1 - 10年累积风险为1.15%[95%置信区间（CI），1.11 - 1.20]，比较队列中为1.00%（95% CI，0.98 - 1.02）。AD的调整后1 - 10年风险比为1.16（95% CI：1.10 - 1.21），全因痴呆症的调整后风险比为1.21（95% CI：1.17 - 1.25）。从随访超过10年至21年，BPH仍然与AD和全因痴呆症风险增加10% - 20%相关。
在长达21年的随访期间，与普通人群中的男性相比，患有BPH的男性患AD和全因痴呆症的风险持续较高。我们的结果确定BPH是一种与痴呆症风险相关的常见、潜在可治疗的疾病。
伦贝克基金会、奥胡斯大学研究基金会和美国国立卫生研究院。
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