在多囊卵巢综合征多毛症患者的激光治疗中添加口服避孕药或二甲双胍。

Adding Combined Oral Contraceptives or Metformin to Laser Treatment in Polycystic Ovarian Syndrome Hirsute Patients.

出版信息

J Drugs Dermatol. 2021 Mar 1;20(3):302-306. doi: 10.36849/JDD.5652.

Abstract

BACKGROUND

Hirsutism is estimated to affect 10% to 20% of females, provoking significant psychological damage and social embarrassment. Polycystic ovary syndrome is a major cause of hirsutism.

AIM

Assessing the impact of adding combined oral contraceptives (COCs) or metformin to laser hair removal on the quality of life of polycystic ovarian syndrome (PCOS) patients with hirsutism.

METHODOLOGY

One-hundred-fifty PCO patients diagnosed with hirsutism were included in this study. Patients were randomized into three groups: group 1 received laser hair removal alone, group 2 received metformin and laser hair removal, and group 3 received COCs and laser hair removal. A diode laser with a wavelength of 810 nm was used for hair removal in all patients according to a protocol of 6 monthly sessions followed by another two sessions after three and six months. Patients were assessed using a visual analog scale (VAS) and Dermatology Life Quality Index (DLQI) and a customized questionnaire (Hirsutism Life Quality Index; HLQI).

RESULTS

All patients showed a significant improvement in both quality indices (DLQI and HLQI) after treatment relative to pretreatment. Group 3 showed significantly better improvements when compared with group 2 and group 1. At three and six months, group 3 showed non-significantly better DLQI and HLQI as compared with at zero months. On the other hand, group 2 patients displayed significant worsening of both DLQI and HLQI scores at three months, with subsequent improvements again at six. Finally, group 1 patients showed nonsignificant worsening at three months, and significant worsening at 6 months.

CONCLUSION

Combining hormonal treatment with laser hair removal can achieve greater hair reduction, significant improvements in patients' QOL, and better maintenance as compared with when combining metformin with laser hair removal or conducting alone. J Drugs Dermatol. 2021;20(3):302-306. doi:10.36849/JDD.5652.

摘要

背景

多毛症估计影响 10%至 20%的女性，引发严重的心理损伤和社交尴尬。多囊卵巢综合征是多毛症的主要原因。

目的

评估在激光脱毛基础上添加复方口服避孕药或二甲双胍对多囊卵巢综合征（PCOS）多毛症患者生活质量的影响。

方法

本研究纳入了 150 例被诊断为多毛症的 PCOS 患者。患者被随机分为三组：第 1 组单独接受激光脱毛，第 2 组接受二甲双胍和激光脱毛，第 3 组接受复方口服避孕药和激光脱毛。所有患者均根据 6 个月 1 次的方案，使用波长为 810nm 的二极管激光进行脱毛，之后 3 个月和 6 个月时再各进行 2 次。使用视觉模拟评分（VAS）和皮肤病生活质量指数（DLQI）和定制问卷（多毛症生活质量指数；HLQI）对患者进行评估。

结果

所有患者治疗后与治疗前相比，两种质量指数（DLQI 和 HLQI）均显著改善。与第 2 组和第 1 组相比，第 3 组的改善更为显著。在 3 个月和 6 个月时，第 3 组与 0 个月时相比，DLQI 和 HLQI 无显著改善。另一方面，第 2 组患者在 3 个月时 DLQI 和 HLQI 评分显著恶化，随后在 6 个月时再次改善。最后，第 1 组患者在 3 个月时无显著恶化，6 个月时显著恶化。