Transthyretin Amyloid Cardiomyopathy-Current and Future Therapies.

OBJECTIVE

To describe the clinical presentation of transthyretin amyloid cardiomyopathy (ATTR-CM) and discuss current treatments and investigational products and their effect on patient outcomes.

DATA SOURCES

A literature search was performed in PubMed (September 2018 to December 2020) using the following keywords: , , , , , , , , , , , , , , , , , and .

STUDY SELECTION AND DATA EXTRACTION

Clinical trials were evaluated for evidence supporting pharmacology, safety, efficacy, and measured outcomes.

DATA SYNTHESIS

Until 2019, there were no approved treatments for ATTR-CM. Treatment consisted of symptom management and organ transplant. Nonpharmacological and pharmacological treatments focused on the symptoms of heart failure (HF) associated with ATTR-CM. However, there are several emerging therapies recently approved or in development to address the underlying pathophysiology. Treatment classes for ATTR-CM include transthyretin stabilizers, human monoclonal antibodies, gene silencers, and CRISPR/Cas9 gene editing.

RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE

ATTR-CM is a complex disease in which amyloidosis causes cardiomyopathy. Underdiagnosis is attributed to the clinical presentation being heterogeneous, indistinguishable from HF caused by other etiologies, and the need for invasive testing modalities, including endomyocardial biopsy. Improved diagnostic approaches along with targeted therapies can slow disease progression and enhance patient quality of life.

CONCLUSION

Diagnostic modalities along with biomarker and genetic testing could detect disease earlier and target therapy more accurately. Novel therapies demonstrate potential treatment benefits and can help shape the standard of care for these patients.