肿瘤微环境中中性粒细胞募集的异质性与前转移龛的形成。
The Heterogeneity of Neutrophil Recruitment in the Tumor Microenvironment and the Formation of Premetastatic Niches.
机构信息
Shanghai Fengxian District Central Hospital, No. 6600, Nanfeng Road, Shanghai, China 201499.
Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 200127.
出版信息
J Immunol Res. 2021 Feb 19;2021:6687474. doi: 10.1155/2021/6687474. eCollection 2021.
Abstract
The recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive. In this review, we discussed emerging research on the interaction between neutrophil recruitment and tumor metastasis, which is essential for studying tumor cell invasion and related immunotherapy.
摘要
已经表明，中性粒细胞向原发性肿瘤的募集是由肿瘤细胞或肿瘤诱导的间充质基质细胞所驱动的，并且具有促转移作用。然而，中性粒细胞的趋化作用及其与远处转移组织中的肿瘤细胞的相互作用仍然难以捉摸。在这篇综述中，我们讨论了中性粒细胞募集与肿瘤转移之间相互作用的新研究，这对于研究肿瘤细胞的侵袭和相关免疫治疗至关重要。
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