Metz J A, Karanja N, Torok J, McCarron D A
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201.
Am J Hypertens. 1988 Jan;1(1):58-60. doi: 10.1093/ajh/1.1.58.
Studies have indicated that spontaneously hypertensive rats (SHRs) consuming diets high in calcium (Ca2+) and sodium (Na+) weigh less compared to SHRs consuming diets lower in Ca2+ and Na+ while consuming similar amounts of food. Based on calcium's known effects on lipid metabolism, it was important to determine if manipulations of dietary Ca2+ and Na+ would modify total body fat in the SHR. Fifteen SHRs and 17 Wistar Kyoto rats (WKY) were randomized at 4 weeks of age to three diets varying in Ca2+ and Na+: 2% Ca2+/1.0% Na+, 1% Ca2+/0.45% Na+, and 0.1% Ca2+/0.25% Na+. At 15 weeks of age, blood pressure, body weight, and body composition were determined. Significant differences in body weight, blood pressure, and total body fat were observed between diet groups in both strains. Dietary Ca2+ and Na+ induced favorable changes in total body fat content in both the SHR and WKY.
研究表明，与摄入钙（Ca2+）和钠（Na+）含量较低饮食的自发性高血压大鼠（SHRs）相比，在摄入相似量食物的情况下，摄入高钙（Ca2+）和高钠（Na+）饮食的自发性高血压大鼠体重更轻。基于钙对脂质代谢的已知影响，确定饮食中Ca2+和Na+的改变是否会改变SHR的全身脂肪量很重要。15只SHR和17只Wistar Kyoto大鼠（WKY）在4周龄时被随机分为三种钙（Ca2+）和钠（Na+）含量不同的饮食组：2% Ca2+/1.0% Na+、1% Ca2+/0.45% Na+和0.1% Ca2+/0.25% Na+。在15周龄时，测定血压、体重和身体组成。在两个品系的饮食组之间观察到体重、血压和全身脂肪存在显著差异。饮食中的Ca2+和Na+在SHR和WKY中均引起了全身脂肪含量的有利变化。
