Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Translational Spine Research Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
World Neurosurg. 2021 Jun;150:e347-e352. doi: 10.1016/j.wneu.2021.03.001. Epub 2021 Mar 8.
Chordomas present challenges for en bloc surgical resection, which optimally reduces local recurrence and increases patient survival. Navigated ultrasonic osteotomy, also known as piezosurgery, provides a distinct advantage for achieving negative margins after en bloc resection.
Eight consecutive patients with chordomas (2 cervical, 3 lumbar, and 3 sacral) treated with navigated ultrasonic osteotomy to achieve en bloc resection were identified from our institutional spine tumor database (2016-2019) and retrospectively reviewed.
En bloc resection, with negative margins, was achieved in all cases. Two patients (25%) were women, and mean age at surgery was 44 ± 11 years. Median estimated blood loss was 1000 mL (interquartile range: 263-1500 mL). Median length of hospital stay was 10 days (interquartile range: 3-19.5 days). Two patients required a revision procedure. Two patients had complications requiring readmission within the 30-day postoperative window. Mean duration of follow-up for the cohort was 900 ± 554 days.
Navigated ultrasonic osteotomy is an effective surgical technique to achieve en bloc resection of chordomas with negative margins and disease-free survival. To date, this represents the first reported cohort of patients undergoing the procedure as described here. Future studies should include larger sample sizes for more robust clinical outcome data to further elucidate the benefits of piezosurgery for obtaining en bloc chordoma resection.
脊索瘤的整块切除具有挑战性,因为这可以最大限度地降低局部复发率并提高患者生存率。导航超声骨切开术,也称为超声骨刀,为整块切除后获得阴性切缘提供了明显优势。
从我们的机构脊柱肿瘤数据库(2016-2019 年)中确定了 8 例连续接受导航超声骨切开术以实现整块切除的脊索瘤患者(2 例颈椎,3 例腰椎,3 例骶骨),并进行回顾性研究。
所有病例均实现了整块切除和阴性切缘。2 例患者(25%)为女性,手术时的平均年龄为 44±11 岁。估计中位出血量为 1000 毫升(四分位距:263-1500 毫升)。中位住院时间为 10 天(四分位距:3-19.5 天)。2 例患者需要进行修订手术。2 例患者在术后 30 天内出现并发症需要再次入院。该队列的平均随访时间为 900±554 天。
导航超声骨切开术是一种有效的手术技术,可实现脊索瘤的整块切除和无病生存,且切缘阴性。迄今为止,这是第一个报告的接受此处描述的该手术的患者队列。未来的研究应包括更大的样本量,以获得更可靠的临床结果数据,从而进一步阐明超声骨刀在获得脊索瘤整块切除中的优势。