Liver Center, Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA.
Expert Rev Gastroenterol Hepatol. 2021 Oct;15(10):1191-1200. doi: 10.1080/17474124.2021.1902803. Epub 2021 Apr 2.
: Since there is increasing number of patients with cirrhosis who require the bariatric procedure due to obesity and obesity-related nonalcoholic steatohepatitis fibrosis, we evaluate the effect of cirrhosis on post-bariatric surgery outcomes.: 2011-2017 National Inpatient Sample was used to isolate bariatric cases, which were stratified by cirrhosis; controls were propensity-score matched to cases and compared to endpoints: mortality, length of stay (LOS), costs, and postoperative complications.: From 190,753 patients undergoing bariatric surgery, there were 957 with cirrhosis and 957 matched controls. There was no difference in mortality (0.94 vs 0.52% p = 0.42, OR 1.81 95%CI 0.60-5.41); however, cirrhosis patients had higher LOS (3.36 vs 2.89d p = 0.002), costs ($68,671 vs $61,301 p < 0.001), and bleeding (2.09 vs 0.72% p < 0.001, OR 2.95 95%CI 1.89-4.61). In multivariate, there was no difference in mortality (p = 0.330, aOR 1.73 95%CI 0.58-5.19). In subgroup comparison of cirrhosis patients, those with decompensated cirrhosis had higher mortality (7.69 vs 0.94% p < 0.001, OR 8.78 95%CI 3.41-22.59).: The results of this study show compensated cirrhosis does not pose an increased risk toward post-bariatric surgery mortality; however, hepatic decompensation increases the postsurgical risks.
: 由于肥胖和肥胖相关的非酒精性脂肪性肝炎纤维化导致越来越多的肝硬化患者需要进行减肥手术,我们评估了肝硬化对减肥手术后结果的影响。: 使用 2011-2017 年全国住院患者样本分离减肥手术病例,按肝硬化分层;将对照患者与病例进行倾向评分匹配,并比较终点:死亡率、住院时间(LOS)、费用和术后并发症。: 在 190753 例接受减肥手术的患者中,有 957 例患有肝硬化,957 例匹配对照。死亡率无差异(0.94%对 0.52%,p = 0.42,OR 1.81,95%CI 0.60-5.41);然而,肝硬化患者的 LOS 较长(3.36 对 2.89d,p = 0.002),费用较高(68671 美元对 61301 美元,p < 0.001),出血较多(2.09%对 0.72%,p < 0.001,OR 2.95,95%CI 1.89-4.61)。多变量分析时,死亡率无差异(p = 0.330,aOR 1.73,95%CI 0.58-5.19)。在肝硬化患者亚组比较中,失代偿性肝硬化患者死亡率较高(7.69%对 0.94%,p < 0.001,OR 8.78,95%CI 3.41-22.59)。: 本研究结果表明,代偿性肝硬化不会增加减肥手术后的死亡率风险;然而,肝失代偿会增加术后风险。