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肝硬化对接受减重手术患者术后结局的临床影响:2011-2017 年美国医院倾向评分匹配分析。

The clinical impact of cirrhosis on the postoperative outcomes of patients undergoing bariatric surgery: propensity score-matched analysis of 2011-2017 US hospitals.

机构信息

Liver Center, Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA.

出版信息

Expert Rev Gastroenterol Hepatol. 2021 Oct;15(10):1191-1200. doi: 10.1080/17474124.2021.1902803. Epub 2021 Apr 2.

DOI:10.1080/17474124.2021.1902803
PMID:33706616
Abstract

: Since there is increasing number of patients with cirrhosis who require the bariatric procedure due to obesity and obesity-related nonalcoholic steatohepatitis fibrosis, we evaluate the effect of cirrhosis on post-bariatric surgery outcomes.: 2011-2017 National Inpatient Sample was used to isolate bariatric cases, which were stratified by cirrhosis; controls were propensity-score matched to cases and compared to endpoints: mortality, length of stay (LOS), costs, and postoperative complications.: From 190,753 patients undergoing bariatric surgery, there were 957 with cirrhosis and 957 matched controls. There was no difference in mortality (0.94 vs 0.52% p = 0.42, OR 1.81 95%CI 0.60-5.41); however, cirrhosis patients had higher LOS (3.36 vs 2.89d p = 0.002), costs ($68,671 vs $61,301 p < 0.001), and bleeding (2.09 vs 0.72% p < 0.001, OR 2.95 95%CI 1.89-4.61). In multivariate, there was no difference in mortality (p = 0.330, aOR 1.73 95%CI 0.58-5.19). In subgroup comparison of cirrhosis patients, those with decompensated cirrhosis had higher mortality (7.69 vs 0.94% p < 0.001, OR 8.78 95%CI 3.41-22.59).: The results of this study show compensated cirrhosis does not pose an increased risk toward post-bariatric surgery mortality; however, hepatic decompensation increases the postsurgical risks.

摘要

: 由于肥胖和肥胖相关的非酒精性脂肪性肝炎纤维化导致越来越多的肝硬化患者需要进行减肥手术,我们评估了肝硬化对减肥手术后结果的影响。: 使用 2011-2017 年全国住院患者样本分离减肥手术病例,按肝硬化分层;将对照患者与病例进行倾向评分匹配,并比较终点:死亡率、住院时间(LOS)、费用和术后并发症。: 在 190753 例接受减肥手术的患者中,有 957 例患有肝硬化,957 例匹配对照。死亡率无差异(0.94%对 0.52%,p = 0.42,OR 1.81,95%CI 0.60-5.41);然而,肝硬化患者的 LOS 较长(3.36 对 2.89d,p = 0.002),费用较高(68671 美元对 61301 美元,p < 0.001),出血较多(2.09%对 0.72%,p < 0.001,OR 2.95,95%CI 1.89-4.61)。多变量分析时,死亡率无差异(p = 0.330,aOR 1.73,95%CI 0.58-5.19)。在肝硬化患者亚组比较中,失代偿性肝硬化患者死亡率较高(7.69%对 0.94%,p < 0.001,OR 8.78,95%CI 3.41-22.59)。: 本研究结果表明,代偿性肝硬化不会增加减肥手术后的死亡率风险;然而,肝失代偿会增加术后风险。

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引用本文的文献

1
Efficacy and Safety of Bariatric Surgery in Well-Compensated Liver Cirrhosis: A Systematic Review and a Single-Arm Meta-analysis.减肥手术对代偿期肝硬化患者的疗效及安全性:一项系统评价和单臂荟萃分析
Obes Surg. 2025 Sep 3. doi: 10.1007/s11695-025-08189-6.
2
Guidance document: risk assessment of patients with cirrhosis prior to elective non-hepatic surgery.指导文件:择期非肝脏手术前肝硬化患者的风险评估
Frontline Gastroenterol. 2023 Mar 8;14(5):359-370. doi: 10.1136/flgastro-2023-102381. eCollection 2023.