一种用于热消融中消融计划验证的热致变色组织模拟体模模型。
A thermochromic tissue-mimicking phantom model for verification of ablation plans in thermal ablation.
作者信息
Zhou Yan, Zhao Lin, Zhong Xinyu, Ding Jianmin, Zhou Hongyu, Wang Fengmei, Jing Xiang
机构信息
School of Medicine, Nankai University, Tianjin, China.
Department of Ultrasound, Tianjin Third Central Hospital, Tianjin, China.
出版信息
Ann Transl Med. 2021 Feb;9(4):354. doi: 10.21037/atm-21-523.
BACKGROUND
Our study aims to develop a novel tissue-mimicking thermochromic with tumor model for visualization of thermal ablation and verification of ablation plans.
METHODS
Polyacrylamide gel was mixed with thermochromic ink to produce a phantom model. A phantom model embedded in a tumor model was constructed and used to evaluate the ablation procedure. The phantom models were randomly divided into complete ablation group and incomplete ablation group. The ablation planning of the tumor was on the 3D US and performed on a phantom model. We guide the ablation procedures according to the ablation planning. The results measured in a gross specimen of the phantom model were compared with the expected results in ablation planning.
RESULTS
The color of the model changes from cream white to magenta after heating. The mono-site ablation area is a spheroid after thermal ablation with a size of 3.0×1.8 cm at 60 W, 5 minutes, 3.5×2.5 cm at 60 W, 10 minutes, and 4.0×3.5 cm at 60 W, 15 minutes, respectively. According to the ablation planning, a total of 4 ablation points were needed to retrieve the complete ablation of a 3.0 cm tumor. The complete ablation and incomplete ablation were proved by a gross specimen of the phantom model as we expected.
CONCLUSIONS
A novel thermochromic tissue-mimicking phantom model with a spherical tumor model has been designed and developed. The ablation area can be visualized on this phantom model by the permanent color change. This phantom model can assess the ablation planning system's accuracy and train operators for ultrasound-guided thermal ablation.
背景
我们的研究旨在开发一种新型的组织模拟热变色肿瘤模型，用于热消融的可视化和消融计划的验证。
方法
将聚丙烯酰胺凝胶与热变色墨水混合以制作体模模型。构建一个嵌入肿瘤模型的体模模型并用于评估消融过程。将体模模型随机分为完全消融组和不完全消融组。在三维超声上进行肿瘤的消融规划，并在体模模型上实施。我们根据消融规划指导消融操作。将体模模型大体标本中测得的结果与消融规划中的预期结果进行比较。
结果
加热后模型颜色从乳白变为品红。单点消融区域在热消融后呈椭球体，60瓦、5分钟时大小为3.0×1.8厘米，60瓦、10分钟时为3.5×2.5厘米，60瓦、15分钟时为4.0×3.5厘米。根据消融规划，要实现对一个3.0厘米肿瘤的完全消融总共需要4个消融点。如我们所预期，体模模型的大体标本证实了完全消融和不完全消融情况。
结论
设计并开发了一种带有球形肿瘤模型的新型热变色组织模拟体模模型。通过永久性颜色变化可在该体模模型上可视化消融区域。该体模模型可评估消融规划系统的准确性，并培训超声引导热消融的操作人员。
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