不同钙离子通道阻滞剂对多巴胺诱导的体外催乳素分泌抑制作用的影响。

Effect of different Ca2+ entry blockers on dopamine-induced inhibition of in vitro prolactin secretion.

作者信息

Di Renzo G, Amoroso S, Maida P, Canzoniero L, Nappi C, Taglialatela M, Annunzia L

机构信息

Department of Pharmacology, University of Naples, Italy.

出版信息

Eur J Pharmacol. 1988 Feb 9;146(2-3):201-6. doi: 10.1016/0014-2999(88)90293-2.

DOI:10.1016/0014-2999(88)90293-2

PMID:3371396

Abstract

The organic Ca2+ entry blockers nimodipine, verapamil, flunarizine and diltiazem belong to different chemical classes but antagonized, at the concentrations of 1 and 10 microM, the inhibitory effect exerted by 1-10 microM dopamine on in vitro prolactin secretion from the pituitary gland. The results suggest a close functional interaction between Ca2+ entry blockers and the dopamine receptors involved in the inhibition of prolactin secretion.

摘要

有机钙通道阻滞剂尼莫地平、维拉帕米、氟桂利嗪和地尔硫䓬属于不同的化学类别，但在1微摩尔和10微摩尔的浓度下，它们拮抗了1 - 10微摩尔多巴胺对垂体体外催乳素分泌的抑制作用。结果表明钙通道阻滞剂与参与抑制催乳素分泌的多巴胺受体之间存在密切的功能相互作用。