Bernstein E F, Whitington P F
Department of Pediatrics, University of Chicago Pritzker School of Medicine, Wyler Children's Hospital, Illinois.
Gastroenterology. 1988 Jul;95(1):199-204. doi: 10.1016/0016-5085(88)90312-5.
Cyclosporine was used to treat a child with severe, atypical sprue that was unresponsive to diet, parenteral nutrition, and corticosteroids. Therapy with cyclosporine resulted in a prompt clinical, functional, and histologic recovery. Remission was maintained for 1 yr until the drug was discontinued, when there was a histologic relapse that responded to reinstituting drug therapy. Cyclosporine may provide effective therapy for patients with similar disease.