DNAJC12作为乳腺癌细胞中ESR1和ERBB4之间的介质。
DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells.
作者信息
Lin Mianjie, Wang Ya-Nan, Ye Yixin, Xiong Zhelei, Guo Fengbiao, Chen Haibin
机构信息
Guangdong Provincial Key Laboratory of Breast Cancer Diagnosis and Treatment, Shantou University Medical College, Shantou, China.
Department of Histology and Embryology, Shantou University Medical College, Shantou, China.
出版信息
Front Oncol. 2021 Feb 24;11:582277. doi: 10.3389/fonc.2021.582277. eCollection 2021.
Mutation of the DNAJC12 gene is typically associated with non-progressive Parkinsonism, but is also detectable in breast carcinoma where its contribution and mechanisms are unexplored. In breast carcinoma, ESR1 was positively correlated with DNAJC12 and ERBB4, and DNAJC12 was positively correlated with ERBB4. We used the GEO2R tool to compare differential gene expression of MCF-7 cells, following ESR1 knockdown (GEO database, E-GEOD-27473 array), and found decreased expression of DNAJC12 and ERBB4 in ESR1-silenced MCF-7 cells. The number of identical genes having correlativity with ESR1, DNAJC12, or ERBB4 was 12,165 (66.41%). These results suggest that ESR1 can promote the expression of DNAJC12 and ERBB4, and DNAJC12 can enhance the expression of ERBB4 in MCF-7 cells, implying that there may be a regulatory network among these three genes.
DNAJC12基因的突变通常与非进行性帕金森症相关，但在乳腺癌中也可检测到，其在乳腺癌中的作用和机制尚不清楚。在乳腺癌中，ESR1与DNAJC12和ERBB4呈正相关，而DNAJC12与ERBB4呈正相关。我们使用GEO2R工具比较了ESR1基因敲低后MCF-7细胞的差异基因表达（GEO数据库，E-GEOD-27473阵列），发现ESR1沉默的MCF-7细胞中DNAJC12和ERBB4的表达降低。与ESR1、DNAJC12或ERBB4具有相关性的相同基因数量为12165个（66.41%）。这些结果表明，ESR1可以促进MCF-7细胞中DNAJC12和ERBB4的表达，而DNAJC12可以增强ERBB4的表达，这意味着这三个基因之间可能存在一个调控网络。
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