Wee Jee Hye, Bang Woo Jin, Park Min Woo, Byun Soo-Hwan, Choi Hyo Geun
Department of Otorhinolaryngology-Head & Neck Surgery.
Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang.
Medicine (Baltimore). 2021 Mar 19;100(11):e25214. doi: 10.1097/MD.0000000000025214.
The purpose of this study was to evaluate the association between asthma and benign prostatic hyperplasia (BPH) in an adult Korean population and to evaluate this association based on the treatment status of asthmatics.We utilized the Korean genome and epidemiology study health examinee 2004 to 2016 database. A total of 47,186 participants (825 asthmatics and 46,361 controls) were selected and their BPH histories were analyzed. We categorized the participants according to their asthma treatment status: "well controlled"; "being treated"; and "not being treated". The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for BPH were analyzed using multiple logistic regression. Subgroup analyses were performed according to age (60 years).The results showed that the prevalence of BPH was higher among asthma patients (17.1%) than among controls (8.7%, P < .001). Asthma patients had a higher risk of having BPH (OR = 1.64, 95% CI = 1.37-2.01, P < .001) than controls, after adjustment for age, income, body mass index (BMI), smoking, alcohol consumption, frequency of physical activity, and the past medical diseases. The ORs for BPH were 1.35 (95% CI = 1.04-1.76) in those aged >60 years and 2.24 (95% CI = 1.70-2.96) in those aged ≤60 years. The ORs for BPH were 1.82 (95% CI = 1.16-2.87, P = .009) in the "well-controlled" group, 1.05 (95% CI = 0.74-1.49, P = .794) in the "being treated" group, and 2.24 (95% CI = 1.69-2.97, P < .001) in the "not being treated" group.We found that there is a correlation between asthma and BPH in the adult Korean population. There is a stronger association between asthma and BPH in younger adults and in those who are not receiving treatment for asthma.
本研究的目的是评估韩国成年人群中哮喘与良性前列腺增生（BPH）之间的关联，并根据哮喘患者的治疗状况评估这种关联。我们利用了韩国基因组与流行病学研究2004年至2016年健康体检者数据库。共选取了47186名参与者（825名哮喘患者和46361名对照），并分析了他们的BPH病史。我们根据参与者的哮喘治疗状况将其分类为：“控制良好”；“正在接受治疗”；以及“未接受治疗”。使用多元逻辑回归分析BPH的校正比值比（OR）和95%置信区间（CI）。根据年龄（60岁）进行亚组分析。结果显示，哮喘患者中BPH的患病率（17.1%）高于对照组（8.7%，P<0.001）。在调整年龄、收入、体重指数（BMI）、吸烟、饮酒、体育活动频率和既往病史后，哮喘患者患BPH的风险（OR=1.64，95%CI=1.37-2.01，P<0.001）高于对照组。60岁以上人群中BPH的OR为1.35（95%CI=1.04-1.76），60岁及以下人群中为2.24（95%CI=1.70-2.96）。“控制良好”组中BPH的OR为1.82（95%CI=1.16-2.87，P=0.009），“正在接受治疗”组中为1.05（95%CI=0.74-1.49，P=0.794），“未接受治疗”组中为2.24（95%CI=1.69-2.97，P<0.001）。我们发现韩国成年人群中哮喘与BPH之间存在相关性。在年轻成年人以及未接受哮喘治疗的人群中，哮喘与BPH之间的关联更强。
