Department of Hepatobiliary Pancreatic Surgery, 1st Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Department of Pathology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Sci Prog. 2021 Jan-Mar;104(1):36850421997273. doi: 10.1177/0036850421997273.
DDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemotherapy, hypoxia, and DNA damage. A number of clinical studies have confirmed that DDIT4 can change the behavior of tumor cells and the prognosis of patients with cancer. However, the role of DDIT4 in promoting or suppressing cancer is still inconclusive. This article summarized the four characteristics of DDIT4 including a mitochondria-related protein, interactions with various protein molecules, immune and metabolic cell related proteins and participator in the oxygen sensing pathway, which may be related to the progress of cancer.
DDIT4 是一种与线粒体和肿瘤相关的蛋白，参与抗肿瘤治疗抵抗、增殖和侵袭等过程。其表达水平在化疗、缺氧和 DNA 损伤等应激下增加。许多临床研究已经证实，DDIT4 可以改变肿瘤细胞的行为和癌症患者的预后。然而，DDIT4 促进或抑制癌症的作用仍存在争议。本文总结了 DDIT4 的四个特征，包括一种与线粒体相关的蛋白、与各种蛋白分子的相互作用、免疫和代谢细胞相关蛋白以及参与氧感应途径，这些特征可能与癌症的进展有关。
