探讨隐睾症中失调的 miRNAs：系统评价。

Exploring dysregulated miRNAs in cryptorchidism: a systematic review.

机构信息

Department of Urology, Capital Institute of Paediatrics, Beijing, China.

出版信息

J Int Med Res. 2021 Mar;49(3):300060521999950. doi: 10.1177/0300060521999950.

DOI:10.1177/0300060521999950

PMID:33729892

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7975578/

Abstract

OBJECTIVE

To identify dysregulated miRNAs in testicular tissues from animal models and patients with cryptorchidism.

METHODS

Databases were systematically searched for studies published before 10 May 2020 that had investigated miRNAs in cryptorchidism. Predicted targets of the identified miRNA biomarkers were obtained by searching TargetScan and Starbase. Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses were subsequently conducted.

RESULTS

Five publications met the eligibility criteria for the review. 21 differentially expressed miRNAs were the most abundantly reported in 185 animal and human tissue samples. Three miRNAs (miR-210, miR-449a and miR-34c) were dysregulated in both animal and human testicular tissues. The top five relevant lncRNAs associated with the miRNAs were NEAT1, KCNQ1OT1, XIST, AC005154.1, and TUG1.

CONCLUSIONS

Further research is warranted to explore the potential of these dysregulated miRNAs as biomarkers or therapeutic targets for male infertility associated with cryptorchidism.

摘要

目的

鉴定隐睾症动物模型和患者睾丸组织中失调的 miRNAs。

方法

系统检索了截至 2020 年 5 月 10 日之前发表的研究隐睾症 miRNA 的文献。通过搜索 TargetScan 和 Starbase 获得鉴定的 miRNA 生物标志物的预测靶标。随后进行基因本体 (GO) 和京都基因与基因组百科全书 (KEGG) 通路富集分析。

结果

有 5 篇文献符合综述的纳入标准。在 185 个人类和动物组织样本中，最常报道的是 21 个差异表达的 miRNAs。在动物和人类睾丸组织中，有 3 个 miRNAs（miR-210、miR-449a 和 miR-34c）失调。与 miRNA 相关的前 5 个相关 lncRNA 是 NEAT1、KCNQ1OT1、XIST、AC005154.1 和 TUG1。