Tokushima Midori, Tago Masaki, Katsuki Naoko E, Yamashita Shu-Ichi
Departmet of General Medicine, Saga University Hospital, Saga, Japan.
Departmet of General Medicine, Saga University Hospital, Saga, Japan
BMJ Case Rep. 2021 Mar 17;14(3):e239422. doi: 10.1136/bcr-2020-239422.
A 75-year-old woman developed redness and swelling on her truncal skin, spreading from the lower abdomen to left thigh, 2 months before being admitted to our hospital. She was urgently hospitalised because of her worsening respiratory condition. On admission, she had reticular telangiectasia, diffuse skin induration on the lower abdomen and panhypopituitarism. She was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by the third random abdominal skin biopsy. After histopathological examination at autopsy, we made a final diagnosis of IVLBCL causing respiratory failure and panhypopituitarism. This is the rare case of IVLBCL-induced panhypopituitarism showing visible skin lesions.
一名75岁女性在入院前2个月,其躯干皮肤出现发红和肿胀,从下腹部蔓延至左大腿。因呼吸状况恶化,她被紧急送往医院。入院时,她有网状毛细血管扩张、下腹部弥漫性皮肤硬结和全垂体功能减退。通过第三次随机腹部皮肤活检,她被诊断为血管内大B细胞淋巴瘤(IVLBCL)。尸检进行组织病理学检查后,我们最终诊断为IVLBCL导致呼吸衰竭和全垂体功能减退。这是IVLBCL引起全垂体功能减退并伴有可见皮肤病变的罕见病例。