Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
RMD Open. 2021 Mar;7(1). doi: 10.1136/rmdopen-2020-001435.
Many autoimmune diseases share common pathogenic mechanisms; however, there are limited studies quantifying the coexistence of autoimmune diseases and associated conditions in patients with juvenile idiopathic arthritis (JIA). This large US-based study estimated and compared the prevalence of multiple coexisting autoimmune diseases in patients with JIA with a general paediatric (GP) patient population.
This retrospective cohort study was conducted using registry data from the Cincinnati Children's Hospital Medical Center (January 2010-October 2018). The prevalence of multiple autoimmune diseases was estimated in patients (age <21 years) with JIA and a control group from the GP patient population. Crude prevalences of 26 prespecified autoimmune diseases and associated conditions were compared using Bayesian Poisson regression modelling for each year up to the end of the study period.
Overall, 2026 patients were included in the JIA cohort and 41 572 in the GP cohort. Of 26 autoimmune diseases and associated conditions evaluated, 14 (53.8%) had a significantly higher prevalence in the JIA cohort compared with the GP cohort. In total, seven (26.9%) autoimmune diseases or associated conditions had a >20-fold increased prevalence in the JIA cohort compared with the GP cohort.
In this study, patients with JIA had a greater prevalence of a large number of coexisting autoimmune diseases and associated conditions compared with the GP population. Physicians should consider coexisting autoimmune diseases in the treatment and management of patients with JIA.
许多自身免疫性疾病具有共同的发病机制；然而，目前评估幼年特发性关节炎（JIA）患者中多种自身免疫性疾病并存及其相关情况的研究有限。本项美国大型研究估计并比较了 JIA 患者与普通儿科（GP）患者群体中多种并存自身免疫性疾病的患病率。
这是一项使用辛辛那提儿童医院医疗中心（2010 年 1 月至 2018 年 10 月）登记数据进行的回顾性队列研究。在 JIA 患者（年龄<21 岁）和 GP 患者群体的对照组中，估计了多种自身免疫性疾病的患病率。使用贝叶斯泊松回归模型比较了研究期间每年 26 种预先指定的自身免疫性疾病和相关疾病的粗患病率。
总体而言，纳入了 2026 名 JIA 患者和 41572 名 GP 患者。在评估的 26 种自身免疫性疾病和相关疾病中，有 14 种（53.8%）在 JIA 患者中比在 GP 患者中更为常见。总共，有 7 种（26.9%）自身免疫性疾病或相关疾病在 JIA 患者中比在 GP 患者中的患病率增加了 20 倍以上。
在这项研究中，与 GP 人群相比，JIA 患者存在大量共存的自身免疫性疾病和相关疾病的患病率更高。医生在治疗和管理 JIA 患者时应考虑并存的自身免疫性疾病。
