Feng Zhicai, Chen Yuqing, Wu Yuqin, Wang Jianwen, Zhang Hao, Zhang Wei
Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
The Graduate School of Fujian Medical University, Fuzhou, Fujian 350108, P.R. China.
Exp Ther Med. 2021 Apr;21(4):361. doi: 10.3892/etm.2021.9792. Epub 2021 Feb 13.
Since 2003, coronaviruses have caused multiple global pandemic diseases, including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19). Clinical and autopsy findings suggest that the occurrence of kidney injury during infection may negatively affect the clinical outcomes of infected patients. The authoritative model predicts that outbreaks of other novel coronavirus pneumonias will continue to threaten human health in the future. The aim of the present systematic review was to summarize the basic knowledge of coronavirus, coronavirus infection-associated kidney injury and the corresponding therapies, in order to provide new insights for clinicians to better understand the kidney involvement of coronavirus so that more effective therapeutic strategies can be employed against coronavirus infection in the future.
自2003年以来,冠状病毒已引发多次全球大流行疾病,包括严重急性呼吸综合征(SARS)、中东呼吸综合征(MERS)和2019冠状病毒病(COVID-19)。临床和尸检结果表明,感染期间发生肾损伤可能会对感染患者的临床结局产生负面影响。权威模型预测,未来其他新型冠状病毒肺炎的爆发将继续威胁人类健康。本系统综述的目的是总结冠状病毒的基础知识、冠状病毒感染相关的肾损伤及相应治疗方法,以便为临床医生提供新的见解,使其更好地了解冠状病毒感染时肾脏受累情况,从而在未来针对冠状病毒感染采用更有效的治疗策略。