Kostrova G N, Malyavskaya S I, Lebedev A V
Nothern State Medical University of Ministry of Healthcare of the Russian Federation, 163000, Arkhangelsk, Russian Federation.
Vopr Pitan. 2021;90(1):57-64. doi: 10.33029/0042-8833-2021-90-1-57-64. Epub 2021 Jan 20.
Obesity in childhood and adolescence is an important clinical and social problem in all countries, due to its extremely adverse long-term health effects. Vitamin D deficiency is extremely widespread in the world. Obesity and metabolic syndrome are often associated with vitamin D deficit. The role of vitamin D deficiency in obesity and metabolic syndrome in childhood is not well understood. - to study the relationship of vitamin D deficiency and carbohydrate metabolism parameters in school children with obesity. . The cross-sectional study included 71 patients of the Arkhangelsk Children's Clinical Hospital named after P.G. Vyhletsova (32 boys, 39 girls, aged 10 to 15 years, all children live in Arkhangelsk) with abdominal obesity. An anthropometric study was conducted: height (cm), body weight (kg), waist circumference (cm), body mass index (BMI). Serum 25(ОН)D level, fasting glycemia, insulin level and HOMA-IR index were assessed. . It has been revealed that 98,6% of children have vitamin D deficiency of varying severity. 25(OH)D level in severely obese children (BMI>3SDS) was significantly lower than in other obese children (BMI<3SDS): 12.8 [7.3-14.9] vs 13.5 [8.9-18.2] ng/ml, (p=0.039). In children with hyperglycemia and insulin resistance, 25(OH)D levels were significantly lower compared with those who had normal glycemic parameters and HOMA-IR index. . The high prevalence of vitamin D deficiency in children and adolescents with overweight and obesity, progressing with increasing obesity severity, has been demonstrated. The association of glucose metabolism disorders with vitamin D deficiency has been shown.
由于儿童期和青少年期肥胖具有极其不利的长期健康影响，因此在所有国家都是一个重要的临床和社会问题。维生素D缺乏在全球极为普遍。肥胖和代谢综合征常与维生素D缺乏相关。维生素D缺乏在儿童肥胖和代谢综合征中的作用尚未完全明确。——研究肥胖学龄儿童维生素D缺乏与碳水化合物代谢参数之间的关系。横断面研究纳入了以P.G.维赫廖佐娃命名的阿尔汉格尔斯克儿童临床医院的71例腹部肥胖患者（32名男孩，39名女孩，年龄10至15岁，所有儿童均居住在阿尔汉格尔斯克）。进行了人体测量学研究：身高（厘米）、体重（千克）、腰围（厘米）、体重指数（BMI）。评估了血清25(OH)D水平、空腹血糖、胰岛素水平和HOMA-IR指数。研究发现，98.6%的儿童存在不同程度的维生素D缺乏。重度肥胖儿童（BMI>3SDS）的25(OH)D水平显著低于其他肥胖儿童（BMI<3SDS）：12.8 [7.3 - 14.9] 对比13.5 [8.9 - 18.2] 纳克/毫升，（p = 0.039）。与血糖参数和HOMA-IR指数正常的儿童相比，高血糖和胰岛素抵抗儿童的25(OH)D水平显著更低。超重和肥胖的儿童及青少年中维生素D缺乏的高患病率已得到证实，且随着肥胖严重程度的增加而升高。已表明葡萄糖代谢紊乱与维生素D缺乏有关。
