Department of Obstetrics and Gynecology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
JBRA Assist Reprod. 2021 Jul 21;25(3):383-389. doi: 10.5935/1518-0557.20200106.
The present study aims to assess the success of controlled ovarian stimulation in intrauterine insemination cycles stimulated by recombinant-FSH and Clomiphene citrate for either mono- or bi-follicular development.
We assessed 870 infertile patients treated with controlled ovarian stimulation in intrauterine insemination cycles at a university-based infertility clinic between January 2012 and December 2017. We compared the cycles stimulated by clomiphene citrate and recombinant-FSH in two set-ups; mono- and bi-follicular development. The main outcome measure was the clinical pregnancy rate per cycle.
The demographic and cycle parameters were similar between the groups, except for endometrial thickness on the day of hCG administration, which was higher in the recombinant-FSH group than the clomiphene citrate group. The overall clinical pregnancy rates in clomiphene citrate and recombinant-FSH groups were 9.8% and 10.3%, respectively (p=0.940). Regarding the entire cohort, clinical pregnancy was significantly higher in cases of bi-follicular development when compared to mono-follicular development (16.8% vs. 10.2%, respectively; p=0.009).
Clomiphene citrate and recombinant-FSH have similar success rates in terms of clinical pregnancy, in either mono-follicular development or bi-follicular development. Clomiphene citrate and recombinant-FSH cycles resulted in comparable rates of bi-follicular development, which significantly increases clinical pregnancy rate. Clomiphene citrate and recombinant-FSH have similar success rates in terms of clinical pregnancy, in either mono-follicular development or bi-follicular development.
本研究旨在评估使用重组促卵泡激素（FSH）和枸橼酸氯米酚刺激单卵泡或双卵泡发育的宫腔内人工授精周期中控制性卵巢刺激的成功率。
我们评估了 2012 年 1 月至 2017 年 12 月在一家大学不孕不育诊所接受控制性卵巢刺激宫腔内人工授精周期治疗的 870 例不孕患者。我们比较了枸橼酸氯米酚和重组 FSH 在两种方案中单卵泡和双卵泡发育刺激周期的情况。主要观察指标为每个周期的临床妊娠率。
两组患者的人口统计学和周期参数相似，但 hCG 给药日的子宫内膜厚度除外，重组 FSH 组高于枸橼酸氯米酚组。枸橼酸氯米酚组和重组 FSH 组的总临床妊娠率分别为 9.8%和 10.3%（p=0.940）。对于整个队列，与单卵泡发育相比，双卵泡发育的临床妊娠率显著更高（分别为 16.8%和 10.2%；p=0.009）。
在单卵泡发育或双卵泡发育中，枸橼酸氯米酚和重组 FSH 的临床妊娠成功率相似。枸橼酸氯米酚和重组 FSH 周期导致双卵泡发育的比例相当，这显著提高了临床妊娠率。在单卵泡发育或双卵泡发育中，枸橼酸氯米酚和重组 FSH 的临床妊娠成功率相似。
