National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt Wayte Ave, Framingham, MA 01702, USA.
Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Cardiovasc Res. 2021 Jun 16;117(7):1632-1644. doi: 10.1093/cvr/cvab073.
Atrial fibrillation (AF) is a common cardiac arrhythmia leading to many adverse outcomes and increased mortality. Yet the molecular mechanisms underlying AF remain largely unknown. Recent advances in high-throughput technologies make large-scale molecular profiling possible. In the past decade, multiomics studies of AF have identified a number of potential biomarkers of AF. In this review, we focus on the studies of multiomics profiles with AF risk. We summarize recent advances in the discovery of novel biomarkers for AF through multiomics studies. We also discuss limitations and future directions in risk assessment and discovery of therapeutic targets for AF.
心房颤动（AF）是一种常见的心律失常，可导致许多不良后果和死亡率增加。然而，AF 的分子机制在很大程度上仍不清楚。高通量技术的最新进展使得大规模的分子谱分析成为可能。在过去的十年中，AF 的多组学研究已经确定了许多 AF 的潜在生物标志物。在这篇综述中，我们重点关注与 AF 风险相关的多组学研究。我们总结了通过多组学研究发现 AF 新型生物标志物的最新进展。我们还讨论了 AF 风险评估和治疗靶点发现中的局限性和未来方向。
