一种用于预测成人Xp11.2易位性肾细胞癌的新风险评分系统。

A new risk-scoring system to predict Xp11.2 translocation renal cell carcinoma in adults.

作者信息

Shi Qiancheng, Liu Ning, Zhu Yiqi, Qu Feng, Xu Linfeng, Li Xiaogong, Zhang Gutian, Guo Hongqian, Li Dongmei, Gan Weidong

机构信息

Department of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu, China.

出版信息

J Int Med Res. 2021 Mar;49(3):300060521997661. doi: 10.1177/0300060521997661.

DOI:10.1177/0300060521997661

PMID:33752453

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7995454/

Abstract

OBJECTIVE

The objective was to derive and validate a practical scoring system for preoperative diagnosis of Xp11.2 translocation renal cell carcinoma (RCC) in adults.

METHODS

Epidemiology, symptomatology, and imaging methods were correlated between patients with common RCC and those with Xp11.2 translocation RCC using a derivation study (N = 6352) and a validation study (N = 127). Univariate analysis of risk factors was performed to derive a scoring system to predict the occurrence of Xp11.2 translocation RCC in adults. The Hosmer-Lemeshow goodness-of-fit test and receiver operating characteristic (ROC) curve were used to validate the scoring system.

RESULTS

Based on odd ratios, three low-risk factors (sex, gross haematuria, and intratumoural calcification) and three high-risk factors (age, unenhanced computed tomography density, and enhancement pattern) were given weighted scores of 1 and 2, respectively. Patients who scored 3 to 5 points underwent an additional magnetic resonance imaging examination. The final scoring system had a sensitivity of 81.0% and a specificity of 98.0%.

CONCLUSION

We established a practical scoring system for the preoperative diagnosis of Xp11.2 translocation RCC in adults, which can be optimised through further clinical findings in the future.

摘要

目的

旨在推导并验证一种用于成人Xp11.2易位性肾细胞癌（RCC）术前诊断的实用评分系统。

方法

利用一项推导研究（N = 6352）和一项验证研究（N = 127），对常见RCC患者与Xp11.2易位性RCC患者之间的流行病学、症状学及影像学方法进行相关性分析。对风险因素进行单因素分析，以推导一个预测成人Xp11.2易位性RCC发生的评分系统。采用Hosmer-Lemeshow拟合优度检验和受试者工作特征（ROC）曲线对该评分系统进行验证。