Shi Qiancheng, Liu Ning, Zhu Yiqi, Qu Feng, Xu Linfeng, Li Xiaogong, Zhang Gutian, Guo Hongqian, Li Dongmei, Gan Weidong
Department of Urology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu, China.
J Int Med Res. 2021 Mar;49(3):300060521997661. doi: 10.1177/0300060521997661.
The objective was to derive and validate a practical scoring system for preoperative diagnosis of Xp11.2 translocation renal cell carcinoma (RCC) in adults.
Epidemiology, symptomatology, and imaging methods were correlated between patients with common RCC and those with Xp11.2 translocation RCC using a derivation study (N = 6352) and a validation study (N = 127). Univariate analysis of risk factors was performed to derive a scoring system to predict the occurrence of Xp11.2 translocation RCC in adults. The Hosmer-Lemeshow goodness-of-fit test and receiver operating characteristic (ROC) curve were used to validate the scoring system.
Based on odd ratios, three low-risk factors (sex, gross haematuria, and intratumoural calcification) and three high-risk factors (age, unenhanced computed tomography density, and enhancement pattern) were given weighted scores of 1 and 2, respectively. Patients who scored 3 to 5 points underwent an additional magnetic resonance imaging examination. The final scoring system had a sensitivity of 81.0% and a specificity of 98.0%.
We established a practical scoring system for the preoperative diagnosis of Xp11.2 translocation RCC in adults, which can be optimised through further clinical findings in the future.
旨在推导并验证一种用于成人Xp11.2易位性肾细胞癌（RCC）术前诊断的实用评分系统。
利用一项推导研究（N = 6352）和一项验证研究（N = 127），对常见RCC患者与Xp11.2易位性RCC患者之间的流行病学、症状学及影像学方法进行相关性分析。对风险因素进行单因素分析，以推导一个预测成人Xp11.2易位性RCC发生的评分系统。采用Hosmer-Lemeshow拟合优度检验和受试者工作特征（ROC）曲线对该评分系统进行验证。
基于比值比，三个低风险因素（性别、肉眼血尿和肿瘤内钙化）和三个高风险因素（年龄、未增强计算机断层扫描密度和强化模式）分别给予加权分数1分和2分。得分为3至5分的患者需额外进行磁共振成像检查。最终的评分系统敏感性为81.0%，特异性为98.0%。
我们建立了一种用于成人Xp11.2易位性RCC术前诊断的实用评分系统，未来可通过进一步的临床发现对其进行优化。
