Department of Pharmacy and Therapeutics, School of Pharmacy, Center for Critical Care Nephrology, School of Medicine, University of Pittsburgh, PRESBY/SHY Pharmacy Administration Building, 3507 Victoria Street, Mailcode PFG-01-01-01, Pittsburgh, PA 15213, USA.
Crit Care Clin. 2021 Apr;37(2):303-320. doi: 10.1016/j.ccc.2020.11.002. Epub 2021 Feb 13.
Drugs are the third leading cause of acute kidney injury (AKI) in critically ill patients. Nephrotoxin stewardship ensures a structured and consistent approach to safe medication use and prevention of patient harm. Comprehensive nephrotoxin stewardship requires coordinated patient care management strategies for safe medication use, ensuring kidney health, and avoiding unnecessary costs to improve the use of nephrotoxins, renally eliminated drugs, and kidney disease treatments. Implementing nephrotoxin stewardship reduces medication errors and adverse drug events, prevents or reduces severity of drug-associated AKI, prevents progression to or worsening of chronic kidney disease, and alleviates financial burden on the health care system.
药物是危重症患者急性肾损伤（AKI）的第三大主要原因。肾毒物管理确保了安全用药和预防患者伤害的结构化和一致方法。全面的肾毒物管理需要协调患者护理管理策略，以确保安全用药、肾脏健康，并避免不必要的费用，以改善肾毒物、肾清除药物和肾脏疾病治疗的使用。实施肾毒物管理可减少药物错误和药物不良事件，预防或减少与药物相关的 AKI 的严重程度，预防或改善慢性肾脏病的进展和恶化，并减轻医疗保健系统的经济负担。
