Fundamental Research Department, Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Marseille cedex 09, 13288, France.
Cereb Cortex. 2021 Jul 5;31(8):3579-3591. doi: 10.1093/cercor/bhab033.
The rate of cesarean section (CS) delivery has steadily increased over the past decades despite epidemiological studies reporting higher risks of neonatal morbidity and neurodevelopmental disorders. Yet, little is known about the immediate impact of CS birth on the brain, hence the need of experimental studies to evaluate brain parameters following this mode of delivery. Using the solvent clearing method iDISCO and 3D imaging technique, we report that on the day of birth, whole-brain, hippocampus, and striatum volumes are reduced in CS-delivered as compared to vaginally-born mice, with a stronger effect observed in preterm CS pups. These results stress the impact of CS delivery, at term or preterm, during parturition and at birth. In contrast, cellular activity and apoptosis are reduced in mice born by CS preterm but not term, suggesting that these early-life processes are only impacted by the combination of preterm birth and CS delivery.
剖宫产率（CS）尽管在过去几十年中稳步上升，但流行病学研究报告称，其新生儿发病率和神经发育障碍的风险更高。然而，人们对 CS 分娩对大脑的即时影响知之甚少，因此需要进行实验研究来评估这种分娩方式后的大脑参数。使用溶剂清除方法 iDISCO 和 3D 成像技术，我们报告说，在出生当天，与阴道分娩的小鼠相比，CS 分娩的小鼠全脑、海马体和纹状体体积减少，在早产 CS 幼鼠中观察到更强的影响。这些结果强调了 CS 分娩在分娩期间和出生时对足月或早产的影响。相比之下，CS 早产而非足月分娩的小鼠的细胞活性和细胞凋亡减少，这表明这些早期生命过程仅受早产和 CS 分娩的组合影响。
