Multi-Omics Innovative Research Center of Forensic Identification; Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, People's Republic of China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, People's Republic of China.
Leg Med (Tokyo). 2021 May;50:101871. doi: 10.1016/j.legalmed.2021.101871. Epub 2021 Mar 17.
To investigate the genetic polymorphisms of 59 Y-chromosomal short tandem repeat (Y-STR) loci in the Yulin Han population, 229 unrelated healthy male individuals were analyzed using AGCU Y37 kit and AGCU Y-SUPP Plus kit. A total of 227 different haplotypes were obtained at the 59 Y-STR loci. Among them, 225 haplotypes were unique and 2 haplotypes occurred twice. The overall haplotypic diversity and discrimination capacity were 0.9999 and 0.9913, respectively. The phylogenetic relationships between the studied Yulin Han population and 17 previously reported reference populations were evaluated via multidimensional scaling and Neighbor-Joining analyses based on the haplotypic frequencies of 'YHRD Maximal Loci'. Phylogenetic analysis revealed that Yulin Han population was closely related to Chinese Han and Hunan Yao populations. These results demonstrated that the 59 Y-STR loci were useful for forensic applications and population genetic studies.
为了研究榆林汉族人群中 59 个 Y 染色体短串联重复（Y-STR）位点的遗传多态性，使用 AGCU Y37 试剂盒和 AGCU Y-SUPP Plus 试剂盒对 229 名无关健康男性个体进行了分析。在 59 个 Y-STR 位点共获得 227 种不同的单倍型。其中，225 种单倍型为独特单倍型，2 种单倍型出现了 2 次。总体单倍型多样性和区分能力分别为 0.9999 和 0.9913。基于“YHRD 最大位点”的单倍型频率，通过多维尺度分析和邻接法对研究的榆林汉族人群与 17 个先前报道的参考人群之间的系统发育关系进行了评估。系统发育分析表明，榆林汉族人群与中国汉族和湖南瑶族人群密切相关。这些结果表明，59 个 Y-STR 位点可用于法医学应用和群体遗传学研究。
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