Stoecker Jordan B, Wang Grace J
Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, Maloney 4th Floor, Philadelphia, PA 19104.
Division of Vascular Surgery and Endovascular Therapy, Hospital of the University of Pennsylvania, 3400 Spruce Street, Maloney 4th Floor, Philadelphia, PA 19104.
Semin Vasc Surg. 2021 Mar;34(1):18-28. doi: 10.1053/j.semvascsurg.2021.02.001. Epub 2021 Feb 4.
Thoracoabdominal aortic aneurysms, although rare, continue to be associated with high morbidity and mortality in the modern era of vascular surgery, and knowledge of this disease is essential for those in clinical practice. Given the clinically silent nature of the disease, it is difficult to determine disease incidence, with most epidemiologic recommendations not made based on evidence regarding those diagnosed with the disease, but extrapolated from data on surgical outcomes. It appears that although men are more likely to develop thoracoabdominal aortic aneurysms, the distribution is not as skewed as in abdominal aortic aneurysms. Current evidence suggests that Black and Hispanic patients continue to have disproportionately poor disease outcomes, mostly attributed to later presentation and undergoing interventions at lower-volume centers. Although select patients meet criteria for disease screening based on personal or family history of aneurysmal disease, general population screening has not been recommended by any professional organization to date. Vascular surgeons need to continue to be at the forefront of thoracoabdominal aortic aneurysm management, especially as care becomes centered around comprehensive "aortic care centers" and as more endovascular therapies become available.
胸腹主动脉瘤虽然罕见,但在现代血管外科时代,其发病率和死亡率仍然很高,临床医生必须了解这种疾病。鉴于该疾病在临床上无症状的特性,很难确定其发病率,大多数流行病学建议并非基于对已确诊患者的证据,而是从手术结果数据推断得出。虽然男性似乎更易患胸腹主动脉瘤,但这种分布不像腹主动脉瘤那样不均衡。目前的证据表明,黑人和西班牙裔患者的疾病预后仍然较差,这主要归因于就诊较晚以及在手术量较少的中心接受治疗。尽管部分患者因个人或家族动脉瘤病史符合疾病筛查标准,但迄今为止,尚无任何专业组织推荐对普通人群进行筛查。血管外科医生需要继续站在胸腹主动脉瘤治疗的前沿,尤其是随着医疗服务围绕综合性“主动脉治疗中心”展开,以及更多血管内治疗方法的出现。