Sharif Shayka, Saleem Amber, Koumadoraki Evgenia, Jarvis Sommer, Madouros Nikolaos, Khan Safeera
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2021 Feb 17;13(2):e13398. doi: 10.7759/cureus.13398.
Migraine and other types of headaches have several symptoms associated with them. The association between migraine and dementia has been considered. It is a topic of discussion and appears to be multifactorial. Dementia is a cluster of symptoms, with memory loss and cognitive dysfunction being the prominent symptoms. In this review, we discussed the association of headache and cognitive dysfunction in a broader context and how the practiced treatment of headaches may silently lead to dementia. We conducted a thorough literature search using PubMed as our main database. The articles exploring the association between headache (both migraine and non-migraine) and dementia were included. Some risk factors like migraine-induced stroke and inherent vascular diseases in migraine patients channeling to stroke and dementia were not considered. A total of 28 studies were included for review. All the reviewed studies put together showed an association between headache and cognitive dysfunction of any form. They showed that the frequency and duration of headache is a determinant for dementia. Few studies also focused on how treating headaches with certain drugs can lead to dementia. The reviewed published literature showed that headaches of any sort and their treatment are potentially linked to dementia. Not all headache patients will require medical treatment, as the benefit might outweigh the risk sometimes. It is interim to understand these facts and formulate a better protocol for treating headache patients. However, due to some discordant results, further studies are needed.
偏头痛和其他类型的头痛有多种与之相关的症状。偏头痛与痴呆症之间的关联已受到关注。这是一个讨论的话题，且似乎是多因素的。痴呆症是一组症状，其中记忆力丧失和认知功能障碍是突出症状。在本综述中，我们在更广泛的背景下讨论了头痛与认知功能障碍的关联，以及头痛的常规治疗可能如何悄无声息地导致痴呆症。我们以PubMed作为主要数据库进行了全面的文献检索。纳入了探讨头痛（包括偏头痛和非偏头痛）与痴呆症之间关联的文章。一些危险因素，如偏头痛诱发的中风以及偏头痛患者中导致中风和痴呆症的内在血管疾病未被考虑在内。总共纳入了28项研究进行综述。所有纳入综述的研究综合起来表明头痛与任何形式的认知功能障碍之间存在关联。它们表明头痛的频率和持续时间是痴呆症的一个决定因素。少数研究还关注了用某些药物治疗头痛如何导致痴呆症。已发表的综述文献表明，任何类型的头痛及其治疗都可能与痴呆症有关。并非所有头痛患者都需要药物治疗，因为有时益处可能超过风险。了解这些事实并制定更好的头痛患者治疗方案是当务之急。然而，由于一些不一致的结果，还需要进一步研究。
