Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Int J Oncol. 2021 May;58(5). doi: 10.3892/ijo.2021.5201. Epub 2021 Mar 24.
Nuclear protein‑1 (NUPR1) is also known as Com‑1 or p8. It is a protein primarily found in the nucleus of various cells, including cancer cells, and it has been found to play an important role in cell stress and stress‑related apoptosis. Over the past two decades, NUPR1 has been firmly indicated to play a role in the development and progression of numerous types of cancer, as well as in a number of other pathological conditions, including pancreatitis, diabetes, neurological and inflammatory conditions. The past decade has witnessed a rapid understanding of the biological and cellular mechanisms through which NUPR1 operates on cells and the identification of new variant of the protein. Most importantly, there have been comprehensive studies on the clinical and pathological aspects of NUPR1 and its variant in multiple malignancies and identification of therapeutic methods by targeting the protein. The present review aimed to summarise the current knowledge relating to NUPR1 in human malignancies and to discuss the associated controversies and potential future prospects of this molecule.
核蛋白 1（NUPR1）也被称为 Com-1 或 p8。它是一种主要存在于各种细胞（包括癌细胞）核中的蛋白质，已被发现在细胞应激和应激相关细胞凋亡中发挥重要作用。在过去的二十年中，NUPR1 已被明确表明在多种癌症的发展和进展中发挥作用，以及在其他一些病理状况中发挥作用，包括胰腺炎、糖尿病、神经和炎症状况。过去十年见证了对 NUPR1 作用于细胞的生物学和细胞机制的快速理解，以及对该蛋白新变体的识别。最重要的是，已经对 NUPR1 及其在多种恶性肿瘤中的变体的临床和病理方面进行了全面研究，并通过针对该蛋白确定了治疗方法。本综述旨在总结 NUPR1 在人类恶性肿瘤中的最新知识，并讨论该分子的相关争议和潜在未来前景。
