Traditional Chinese Medicine College of Shandong University of Traditional Chinese Medicine, Jinan, China.
The First Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan, China.
Biomed Pharmacother. 2021 May;137:111404. doi: 10.1016/j.biopha.2021.111404. Epub 2021 Mar 2.
Tanshinone IIA (Tan IIA) is the most abundant lipid-soluble component in Salvia miltiorrhiza. Both Tan IIA and its derivatives including Sodium tanshinone IIA sulfonate (STS) have been widely used in clinic due to their proved anti-inflammation, anti-oxidation, and anti-fibrosis functions. Recently, combinations containing Tan IIA and active components have attracted intensive interest in fibrosis. Multiple studies have been conducted to attempt to decipher the mechanisms of this traditional Chinese medicine and found that Tan IIA can attenuate fibrosis through different pathways such as Smad2/3, NF-κB, Nrf2, E2F and snail/twist axis. However, some of the studies were contradictory and confusing. Therefore, it was important to develop an easy-to-access reference for clinic use. In this study, we reviewed the pharmacological mechanisms, pharmacokinetics, and toxicology of Tan IIA and its derivatives in the treatment of fibrosis and introduced the cutting-edge new formulation of Tan IIA compound.
丹参酮 IIA（Tan IIA）是丹参中最丰富的脂溶性成分。由于具有抗炎、抗氧化和抗纤维化作用，Tan IIA 及其衍生物如丹参酮 IIA 磺酸钠（STS）已广泛应用于临床。最近，含有 Tan IIA 和活性成分的组合在纤维化方面引起了广泛关注。多项研究试图解析这种中药的作用机制，发现 Tan IIA 可以通过不同途径减轻纤维化，如 Smad2/3、NF-κB、Nrf2、E2F 和 snail/twist 轴。然而，一些研究结果相互矛盾，令人困惑。因此，为临床应用开发一个易于获取的参考资料非常重要。在本研究中，我们综述了 Tan IIA 及其衍生物在治疗纤维化中的药理学机制、药代动力学和毒理学，并介绍了 Tan IIA 复方的最新制剂。
