针刺治疗儿童抽动障碍的系统评价和荟萃分析方案。
Acupuncture for treating tic disorders in children: A protocol for systematic review and meta-analysis.
机构信息
Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Xiqing.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Xiqing.
出版信息
Medicine (Baltimore). 2021 Mar 26;100(12):e24860. doi: 10.1097/MD.0000000000024860.
BACKGROUND
Tic disorders (TDs) are a group of neurodevelopmental disorders in children, while pharmacotherapy is often associated with various side effects and has limited clinical effects for some patients, thus significantly affecting patients' quality of life. Studies have found acupuncture shows certain advantages in the treatment of TDs. However, there is no high level of evidence evaluating the effectiveness and safety of acupuncture for children with TDs.
METHODS
Each data of acupuncture for treating TDs will be searched. We will search for related English and Chinese databases. The time is limited from inception until November 2020. The primary outcome is the reduction rate (amount) of tic severity using related scales or methods, and the secondary outcomes include recurrence rate and adverse events. The risk of bias will be assessed, and the RevMan5.3 and Stata14.0 will be performed for meta-analysis. Finally, we will assess the level of the resulting evidence.
RESULTS
The results of the study will synthesize the current evidence and be published in peer-reviewed journals.
CONCLUSIONS
This research aims to provide convincing evidence of the effectiveness and safety of acupuncture for treating TDs in children.
INPLASY REGISTRATION NUMBER
INPLASY2020110050.
背景
抽动障碍（TDs）是一组儿童神经发育障碍，而药物治疗常伴有各种副作用，且对某些患者的临床效果有限，从而显著影响患者的生活质量。研究发现针刺在治疗 TDs 方面具有一定优势。然而，目前尚无高级别证据评估针刺治疗 TDs 儿童的有效性和安全性。
方法
将检索针刺治疗 TDs 的相关数据。我们将检索相关的英文和中文数据库。时间限定为从建库开始至 2020 年 11 月。主要结局是使用相关量表或方法衡量 Tic 严重程度的降低率（幅度），次要结局包括复发率和不良事件。将对偏倚风险进行评估，并使用 RevMan5.3 和 Stata14.0 进行荟萃分析。最后，我们将评估研究结果的证据水平。
结果
本研究将综合目前的证据，并发表在同行评议的期刊上。
结论
本研究旨在为针刺治疗儿童 TDs 的有效性和安全性提供有说服力的证据。
INPLASY 注册号：INPLASY2020110050。
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