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Saa3（血清淀粉样蛋白 A3）、炎症和胆固醇代谢之间的性别二态关系调节小鼠的动脉粥样硬化。

Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.

机构信息

Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition (A.C., S.W., L.G., D.G., K.E.T., J.T., C.S., K.B.R., C.T., T.V., L.J.D.H.), University of Washington, Seattle.

Diabetes Institute (A.C., S.W., L.G., D.G., K.E.T., T.W., J.T., C.S., K.D.O., K.B.R., C.T., T.V., L.J.D.H.), University of Washington, Seattle.

出版信息

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e299-e313. doi: 10.1161/ATVBAHA.121.316066. Epub 2021 Mar 25.

DOI:10.1161/ATVBAHA.121.316066
PMID:33761762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8159856/
Abstract

[Figure: see text].

摘要

[图：见正文]。

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本文引用的文献

[1]
Testosterone stimulates cholesterol clearance from human macrophages by activating LXRα.

Life Sci. 2021-3-15

[2]
Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung.

Front Immunol. 2020

[3]
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.

Circ Res. 2020-7-17

[4]
Presence of serum amyloid A3 in mouse plasma is dependent on the nature and extent of the inflammatory stimulus.

Sci Rep. 2020-6-25

[5]
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Immunity. 2020-6-16

[6]
Macrophage subsets in atherosclerosis as defined by single-cell technologies.

J Pathol. 2020-3-11

[7]
Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2.

Biochem Biophys Res Commun. 2020-1-20

[8]
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

Neuron. 2020-1-2

[9]
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

Nature. 2019-10-9

[10]
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.

N Engl J Med. 2018-11-10

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