Suppr超能文献

心脏手术中口服普瑞巴林:随机对照试验的系统评价和荟萃分析。

Oral Pregabalin in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

机构信息

Department of Anesthesiology of the First People's Hospital of Changde City, Changde, Hunan, China.

Department of Anesthesiology of the Taoyuan County People's Hospital, Changde, Hunan, China.

出版信息

Biomed Res Int. 2021 Mar 3;2021:8835891. doi: 10.1155/2021/8835891. eCollection 2021.

Abstract

BACKGROUND

Pregabalin has received wide clinical attention as a new type of analgesic. We undertake a systematic review and meta-analysis to evaluate the effect of pregabalin on postoperative pain in patients undergoing cardiac surgery.

METHODS

We searched PubMed, Embase, and Cochrane Library (from inception to July 2020) for eligible studies. The primary outcomes were the total morphine consumption at 24 h. A secondary outcome was intraoperative fentanyl consumption, extubation time postoperative, and length of stay in hospital. We calculated pooled weighted mean difference (WMD) or odds ratio (OR) and 95% CIs using random- or fixed-effects models.

RESULTS

Seven trials involving 463 patients were listed. Meta-analysis showed that the total morphine consumption at 24 h in the pregabalin group was significantly less than the control group (WMD: -5.44, 95% CI: -10.42-0.46, = 0.03). We found that there is no significant difference between the two groups in intraoperative fentanyl consumption. Compared with the control group, the length of stay in hospital in the pregabalin group was significantly shorter (WMD = -0.87, 95% CI: -1.42-0.32, = 0.002). And we found that there were no significant differences between the two groups in extubation time (WMD: 17.24, 95% CI: -24.36-58.84, = 0.42).

CONCLUSIONS

Oral pregabalin for cardiac surgery patients can effectively reduce the patient's 24-hour morphine consumption after surgery, shorten the patient's hospital stay, and is more conducive to early postoperative recovery.

摘要

背景

普瑞巴林作为一种新型的镇痛药受到了广泛的临床关注。我们进行了一项系统评价和荟萃分析,以评估普瑞巴林对接受心脏手术的患者术后疼痛的影响。

方法

我们检索了 PubMed、Embase 和 Cochrane Library(从建库到 2020 年 7 月)中符合条件的研究。主要结局指标为术后 24 小时吗啡总消耗量。次要结局指标为术中芬太尼消耗量、拔管时间、术后住院时间。我们使用随机或固定效应模型计算合并加权均数差(WMD)或比值比(OR)及其 95%置信区间。

结果

共纳入 7 项试验,涉及 463 例患者。Meta 分析显示,普瑞巴林组术后 24 小时吗啡总消耗量明显少于对照组(WMD:-5.44,95%CI:-10.42-0.46, = 0.03)。我们发现两组术中芬太尼消耗量无显著差异。与对照组相比,普瑞巴林组的住院时间明显缩短(WMD=-0.87,95%CI:-1.42-0.32, = 0.002)。我们还发现两组拔管时间无显著差异(WMD:17.24,95%CI:-24.36-58.84, = 0.42)。

结论

口服普瑞巴林可有效减少心脏手术患者术后 24 小时吗啡消耗量,缩短患者住院时间,更有利于术后早期恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fa6/7946477/62169f7c02ba/BMRI2021-8835891.001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验