利用诱导多能干细胞衍生血细胞的机制及转化研究进展
Mechanistic and Translational Advances Using iPSC-Derived Blood Cells.
作者信息
Thom Christopher S, Chou Stella T, French Deborah L
机构信息
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
J Exp Pathol (Wilmington). 2020;1(2):36-44. doi: 10.33696/pathology.1.010.
Human induced pluripotent stem cell (iPSC)-based model systems can be used to produce blood cells for the study of both hematologic and non-hematologic disorders. This commentary discusses recent advances that have utilized iPSC-derived red blood cells, megakaryocytes, myeloid cells, and lymphoid cells to model hematopoietic disorders. In addition, we review recent studies that have defined how microglial cells differentiated from iPSC-derived monocytes impact neurodegenerative disease. Related translational insights highlight the utility of iPSC models for studying pathologic anemia, bleeding, thrombosis, autoimmunity, immunodeficiency, blood cancers, and neurodegenerative disease such as Alzheimer's.
基于人诱导多能干细胞（iPSC）的模型系统可用于生成血细胞，以研究血液系统疾病和非血液系统疾病。本评论讨论了利用iPSC衍生的红细胞、巨核细胞、髓系细胞和淋巴细胞来模拟造血系统疾病的最新进展。此外，我们回顾了最近的研究，这些研究确定了从iPSC衍生的单核细胞分化而来的小胶质细胞如何影响神经退行性疾病。相关的转化见解突出了iPSC模型在研究病理性贫血、出血、血栓形成、自身免疫、免疫缺陷、血癌以及阿尔茨海默病等神经退行性疾病方面的实用性。
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