Niigata Institute for Health and Sports Medicine, 67-12 Seigorou, Chuoh-ku, Niigata city, Niigata, Japan.
Division of Musculoskeletal Science for Frailty, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuoh-ku, Niigata city, Niigata, Japan.
Clin Biomech (Bristol). 2021 Apr;84:105325. doi: 10.1016/j.clinbiomech.2021.105325. Epub 2021 Mar 17.
Identifying indicators of early knee osteoarthritis is important for preventing the onset and/or progression of the disease. Although low quadriceps strength and changes in stride and knee kinematics during gait have been suggested as possible indicators, their relevance and relationships have not been fully examined. This study aimed to analyze the association of quadriceps strength with stride and knee kinematics during gait in adults with normal knee or early knee osteoarthritis.
A total of 881 knees from 474 community dwelling adults (238 males and 236 females) were included. Radiographic images of the knee in standing position were obtained, and grading of knee osteoarthritis was classified. Isometric quadriceps strength was measured using a force detector device. Three-dimensional knee kinematics during gait was obtained by a motion capture system. Sex-based difference of quadriceps strength, stride and knee kinematics during gait was evaluated by multiple comparison among grades by sex and multiple regression of quadriceps strength was analyzed by stride and knee kinematics during gait.
Stride length and quadriceps strength were significantly reduced with higher grade in both sexes, and changes in knee kinematics during gait differed by sex from early knee osteoarthritis. Quadriceps strength in both sexes was significantly correlated with changes in stride length and knee kinematics during gait.
Improving quadriceps strength in early knee osteoarthritis was related with maintaining gait ability and restraining abnormal knee kinematics during gait. This may help to develop clinical approaches to prevent the onset and/or progression of knee osteoarthritis.
识别早期膝关节骨关节炎的指标对于预防疾病的发生和/或进展非常重要。虽然已经提出股四头肌力量减弱和步态中步幅和膝关节运动学的变化可能是指标，但它们的相关性和关系尚未得到充分研究。本研究旨在分析正常膝关节或早期膝关节骨关节炎成年人中股四头肌力量与步态中步幅和膝关节运动学的关系。
共纳入 474 名社区居住成年人的 881 个膝关节（238 名男性和 236 名女性）。获得膝关节站立位的影像学图像，并对膝关节骨关节炎进行分级。使用力探测器设备测量等速股四头肌力量。通过运动捕捉系统获得步态中膝关节的三维运动学。通过性别间分级的多重比较评估股四头肌力量、步态中步幅和膝关节运动学的性别差异，通过步态中步幅和膝关节运动学分析股四头肌力量的多元回归。
在两性中，随着等级的增加，步幅长度和股四头肌力量显著降低，并且步态中膝关节运动学的变化因性别而异，与早期膝关节骨关节炎不同。两性的股四头肌力量与步幅长度和步态中膝关节运动学的变化显著相关。
在早期膝关节骨关节炎中，股四头肌力量的提高与保持步态能力和抑制异常膝关节运动学有关。这可能有助于开发预防膝关节骨关节炎发生和/或进展的临床方法。
