Bonney C H, Lam K W, Fong D
Department of Ophthalmology, University of Texas Health Science Center, San Antonio.
Ann Ophthalmol. 1988 Apr;20(4):140-2.
Neither the origin nor the role of high levels of uric acid, found in the aqueous humor of some human glaucomatous eyes, is known. A model of hyperuricemia in the rat was evaluated for its contribution to urate levels in the aqueous humor. Epinephrine-induced hyperuricemia in male rats was shown to increase mean serum urate levels from 1.2 mg/dL to 6.7 mg/dL. Female rats were shown to have a lower uric acid baseline and a lower absolute hyperuricemic level than males. The mean aqueous-humor urate levels were increased from 0.06 mg/dL to 0.33 mg/dL for male rats. In our studies, the blood-aqueous barrier effectively prevented equilibration between the systemic and ocular compartments. The increased aqueous-humor uric acid levels in glaucoma may arise from intraocular mechanisms.
在一些人类青光眼患者的房水中发现的高水平尿酸，其来源和作用均尚不明确。我们评估了大鼠高尿酸血症模型对房水中尿酸水平的影响。结果显示，肾上腺素诱导的雄性大鼠高尿酸血症可使平均血清尿酸水平从1.2mg/dL升至6.7mg/dL。雌性大鼠的尿酸基线水平和绝对高尿酸血症水平均低于雄性大鼠。雄性大鼠房水中的平均尿酸水平从0.06mg/dL升至0.33mg/dL。在我们的研究中，血-房水屏障有效阻止了全身和眼内成分之间的平衡。青光眼患者房水中尿酸水平升高可能源于眼内机制。
