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支架型人工血管在血液透析瘘管中的应用:部分血栓形成的动脉瘤和残余血栓的通畅率

Stent graft deployment in haemodialysis fistula: patency rates in partially thrombosed aneurysm and residual thrombi.

作者信息

García-Medina José, Maldonado-Cárceles Ana B, García-Alfonso Juan J, Árense-Gonzalo Julián J, Torres-Cantero Alberto M

机构信息

Department of Vascular and Interventional Radiology, General University Hospital "Reina Sofia", Murcia, Spain.

Division of Preventive Medicine and Public Health, University of Murcia School of Medicine, Murcia, Spain.

出版信息

Clin Kidney J. 2020 Feb 10;14(3):814-819. doi: 10.1093/ckj/sfz193. eCollection 2021 Mar.

Abstract

BACKGROUND

Current evidence is insufficient to determine the contribution of stent grafts as treatment in partially thrombosed aneurysms or residual wall-adherent thrombi in arteriovenous fistulae (AVFs) for haemodialysis. The overall purpose of this study was to analyse patency rates of post-interventional covered stent deployment in those cases. We also assessed if patency rates differed when fistulas were punctured through the stent during dialysis sessions.

METHODS

We conducted a retrospective study between 2006 and 2014 analysing post-intervention primary patency rates using the Kaplan-Meier log-rank test. Multivariate Cox proportional regression models were performed to determine if cannulation within the stent graft area was a potential risk factor for occlusion, by adjusted hazard ratio (HR).

RESULTS

A total of 27 procedures were included in the study. Primary patency rates (%) after stent deployment at 3, 6, 12, 24, 36 and 72 months were, respectively: total 59, 32, 32, 21, 11 and 5; stent puncture 53, 21, 21, 16, 5 and 0; and no stent puncture 80, 80, 80, 40, 40 and 40. Cannulation through the stent graft was not significantly associated with increased risk of obstruction in multivariate analysis (HR = 3.01; P = 0.286).

CONCLUSION

Stent graft treatment may be a feasible procedure in partially thrombosed aneurysms and residual thrombi in AVF. Although fistulas punctured through the stent presented lower patency rates, this practice was not associated with a higher risk of obstruction. Giving the impossibility of comparing with similar approaches, further studies are needed to confirm or refute the advantages of this procedure.

摘要

背景

目前的证据不足以确定覆膜支架作为治疗部分血栓形成的动脉瘤或动静脉内瘘(AVF)中残留壁附着血栓以进行血液透析的作用。本研究的总体目的是分析这些情况下介入后覆膜支架置入的通畅率。我们还评估了在透析期间通过支架穿刺内瘘时通畅率是否有所不同。

方法

我们在2006年至2014年期间进行了一项回顾性研究,使用Kaplan-Meier对数秩检验分析介入后的原发性通畅率。进行多变量Cox比例回归模型以通过调整后的风险比(HR)确定在覆膜支架区域内插管是否是闭塞的潜在危险因素。

结果

本研究共纳入27例手术。支架置入后3个月、6个月、12个月、24个月、36个月和72个月时的原发性通畅率(%)分别为:总体59、32、32、21、11和5;支架穿刺53、21、21、16、5和0;未进行支架穿刺80、80、80、40、40和40。在多变量分析中,通过覆膜支架插管与梗阻风险增加无显著相关性(HR = 3.01;P = 0.286)。

结论

覆膜支架治疗对于部分血栓形成的动脉瘤和AVF中的残留血栓可能是一种可行的方法。尽管通过支架穿刺的内瘘通畅率较低,但这种操作与更高的梗阻风险无关。鉴于无法与类似方法进行比较,需要进一步研究来证实或反驳该方法的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea45/7986443/51c1411b0656/sfz193f1.jpg

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